FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982658102> ?p ?o ?g. }

• W1982658102 endingPage "2833" @default.
• W1982658102 startingPage "2827" @default.
• W1982658102 abstract "Effects of retinoids on DNA synthesis, iodine metabolism, and thyroid peroxidase messenger RNA levels were studied in cultured porcine thyroid cells. Retinol (10−8-10−5m) alone did not affect DNA synthesis but potentiated that induced by epidermal growth factor or insulin-like growth factor-I without changes in the number or affinity of receptors for the growth factors, suggesting that retinol stimulates postreceptor events responsible for DNA synthesis. Retinol was an inhibitor of TSHstimulated iodine metabolism. Iodide uptake and release of organified iodine stimulated by TSH or forskolin were inhibited dose dependently by treatment with retinol. The inhibition was detected at 10−8m and was approximately 50% at 10−6m. The potency of retinoic acid was comparable to that of retinol. The inhibitory effect of retinol was detected after treatments of thyroid cells for 24 h, and the maximal effect occurred after 48 h incubation. The cAMP accumulation in cultures treated with TSH plus retinol was lower than that of control cultures treated with TSH alone. However, iodide uptake stimulated by 8-bromocAMP was also inhibited by retinoids. Retinol reduced TSH- or 8-bromo-cAMP-stimulated gene expression of thyroid peroxidase. Thus, the data suggest that retinoids inhibit TSH-stimulated iodine metabolism by reducing cAMP accumulation and also by acting on the steps subsequent to cAMP production. (Endocrinology129: 2827–2833, 1991)" @default.
• W1982658102 created "2016-06-24" @default.
• W1982658102 creator A5009859251 @default.
• W1982658102 creator A5030293363 @default.
• W1982658102 creator A5033893823 @default.
• W1982658102 creator A5039227191 @default.
• W1982658102 creator A5055696100 @default.
• W1982658102 creator A5063551011 @default.
• W1982658102 creator A5065217658 @default.
• W1982658102 creator A5084837866 @default.
• W1982658102 date "1991-12-01" @default.
• W1982658102 modified "2023-09-25" @default.
• W1982658102 title "Effects of Retinoids on Iodine Metabolism, Thyroid Peroxidase Gene Expression, and Deoxyribonucleic Acid Synthesis in Porcine Thyroid Cells in Culture*" @default.
• W1982658102 cites W1483414037 @default.
• W1982658102 cites W1521909328 @default.
• W1982658102 cites W1673187668 @default.
• W1982658102 cites W1966059689 @default.
• W1982658102 cites W1977726228 @default.
• W1982658102 cites W1984172347 @default.
• W1982658102 cites W1987709054 @default.
• W1982658102 cites W1990729455 @default.
• W1982658102 cites W1993801915 @default.
• W1982658102 cites W1995819790 @default.
• W1982658102 cites W1997752467 @default.
• W1982658102 cites W2001578365 @default.
• W1982658102 cites W2008076873 @default.
• W1982658102 cites W2014024309 @default.
• W1982658102 cites W2022272869 @default.
• W1982658102 cites W2027798343 @default.
• W1982658102 cites W2033493137 @default.
• W1982658102 cites W2042743000 @default.
• W1982658102 cites W2044090640 @default.
• W1982658102 cites W2045208557 @default.
• W1982658102 cites W2048159338 @default.
• W1982658102 cites W2052404056 @default.
• W1982658102 cites W2058080747 @default.
• W1982658102 cites W2059999863 @default.
• W1982658102 cites W2060333964 @default.
• W1982658102 cites W2070196825 @default.
• W1982658102 cites W2080568630 @default.
• W1982658102 cites W2085355931 @default.
• W1982658102 cites W2098692142 @default.
• W1982658102 cites W2101690477 @default.
• W1982658102 cites W2156423290 @default.
• W1982658102 cites W2164660404 @default.
• W1982658102 cites W2407944089 @default.
• W1982658102 cites W2418933801 @default.
• W1982658102 cites W2576734941 @default.
• W1982658102 doi "https://doi.org/10.1210/endo-129-6-2827" @default.
• W1982658102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1659516" @default.
• W1982658102 hasPublicationYear "1991" @default.
• W1982658102 type Work @default.
• W1982658102 sameAs 1982658102 @default.
• W1982658102 citedByCount "22" @default.
• W1982658102 countsByYear W19826581022022 @default.
• W1982658102 crossrefType "journal-article" @default.
• W1982658102 hasAuthorship W1982658102A5009859251 @default.
• W1982658102 hasAuthorship W1982658102A5030293363 @default.
• W1982658102 hasAuthorship W1982658102A5033893823 @default.
• W1982658102 hasAuthorship W1982658102A5039227191 @default.
• W1982658102 hasAuthorship W1982658102A5055696100 @default.
• W1982658102 hasAuthorship W1982658102A5063551011 @default.
• W1982658102 hasAuthorship W1982658102A5065217658 @default.
• W1982658102 hasAuthorship W1982658102A5084837866 @default.
• W1982658102 hasConcept C104317684 @default.
• W1982658102 hasConcept C126322002 @default.
• W1982658102 hasConcept C134018914 @default.
• W1982658102 hasConcept C178790620 @default.
• W1982658102 hasConcept C180650514 @default.
• W1982658102 hasConcept C185592680 @default.
• W1982658102 hasConcept C24998067 @default.
• W1982658102 hasConcept C2776940978 @default.
• W1982658102 hasConcept C2779276759 @default.
• W1982658102 hasConcept C2779573558 @default.
• W1982658102 hasConcept C2781121885 @default.
• W1982658102 hasConcept C526584372 @default.
• W1982658102 hasConcept C539932907 @default.
• W1982658102 hasConcept C552990157 @default.
• W1982658102 hasConcept C55493867 @default.
• W1982658102 hasConcept C62231903 @default.
• W1982658102 hasConcept C64241487 @default.
• W1982658102 hasConcept C71924100 @default.
• W1982658102 hasConcept C86803240 @default.
• W1982658102 hasConceptScore W1982658102C104317684 @default.
• W1982658102 hasConceptScore W1982658102C126322002 @default.
• W1982658102 hasConceptScore W1982658102C134018914 @default.
• W1982658102 hasConceptScore W1982658102C178790620 @default.
• W1982658102 hasConceptScore W1982658102C180650514 @default.
• W1982658102 hasConceptScore W1982658102C185592680 @default.
• W1982658102 hasConceptScore W1982658102C24998067 @default.
• W1982658102 hasConceptScore W1982658102C2776940978 @default.
• W1982658102 hasConceptScore W1982658102C2779276759 @default.
• W1982658102 hasConceptScore W1982658102C2779573558 @default.
• W1982658102 hasConceptScore W1982658102C2781121885 @default.
• W1982658102 hasConceptScore W1982658102C526584372 @default.
• W1982658102 hasConceptScore W1982658102C539932907 @default.
• W1982658102 hasConceptScore W1982658102C552990157 @default.
• W1982658102 hasConceptScore W1982658102C55493867 @default.

• next