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• W1982665126 endingPage "e1001041" @default.
• W1982665126 startingPage "e1001041" @default.
• W1982665126 abstract "The sinoatrial node (SAN) is a complex structure that exhibits anatomical and functional heterogeneity which may depend on: 1) The existence of distinct cell populations, 2) electrotonic influences of the surrounding atrium, 3) the presence of a high density of fibroblasts, and 4) atrial cells intermingled within the SAN. Our goal was to utilize a computer model to predict critical determinants and modulators of excitation and conduction in the SAN. We built a theoretical non-uniform model composed of distinct central and peripheral SAN cells and a uniform model containing only central cells connected to the atrium. We tested the effects of coupling strength between SAN cells in the models, as well as the effects of fibroblasts and interspersed atrial cells. Although we could simulate single cell experimental data supporting the multiple cell type hypothesis, 2D non-uniform models did not simulate expected tissue behavior, such as central pacemaking. When we considered the atrial effects alone in a simple homogeneous uniform model, central pacemaking initiation and impulse propagation in simulations were consistent with experiments. Introduction of fibroblasts in our simulated tissue resulted in various effects depending on the density, distribution, and fibroblast-myocyte coupling strength. Incorporation of atrial cells in our simulated SAN tissue had little effect on SAN electrophysiology. Our tissue model simulations suggest atrial electrotonic effects as plausible to account for SAN heterogeneity, sequence, and rate of propagation. Fibroblasts can act as obstacles, current sinks or shunts to conduction in the SAN depending on their orientation, density, and coupling." @default.
• W1982665126 created "2016-06-24" @default.
• W1982665126 creator A5031553126 @default.
• W1982665126 creator A5035415698 @default.
• W1982665126 date "2010-12-23" @default.
• W1982665126 modified "2023-09-27" @default.
• W1982665126 title "Determinants of Heterogeneity, Excitation and Conduction in the Sinoatrial Node: A Model Study" @default.
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• W1982665126 doi "https://doi.org/10.1371/journal.pcbi.1001041" @default.
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• W1982665126 hasPublicationYear "2010" @default.
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