Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982666967> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1982666967 endingPage "116" @default.
- W1982666967 startingPage "109" @default.
- W1982666967 abstract "A high-throughput, nonradioactive telomerase assay using a europium-labeled oligonucleotide probe and time-resolved fluorescence has been developed to detect PCR-amplified telomerase products. The use of a thermally activated TAQ polymerase, rather than a wax barrier, to implement a PCR hot-start facilitated the use of laboratory automation equipment. Results obtained with this high-throughput protocol correlate well with those obtained with the TRAP protocol. Screening a set of 125,000 compounds from the Berlex library, we identified a set of isothiazolone-containing telomerase inhibitors. The most potent of these inhibitors have submicromolar IC50 values and may be reacting with a telomerase thiol. These compounds may be useful tools to evaluate the effects of telomerase in cancer cells. Drug Dev. Res. 43:109–116, 1998. © 1998 Wiley-Liss, Inc." @default.
- W1982666967 created "2016-06-24" @default.
- W1982666967 creator A5002605219 @default.
- W1982666967 creator A5011289494 @default.
- W1982666967 creator A5022440764 @default.
- W1982666967 creator A5034648363 @default.
- W1982666967 date "1998-02-01" @default.
- W1982666967 modified "2023-09-23" @default.
- W1982666967 title "Identification of a series of potent telomerase inhibitors using a time-resolved fluorescence-based assay" @default.
- W1982666967 cites W1253046850 @default.
- W1982666967 cites W1540861788 @default.
- W1982666967 cites W1543500873 @default.
- W1982666967 cites W1965960192 @default.
- W1982666967 cites W1966427625 @default.
- W1982666967 cites W1967135627 @default.
- W1982666967 cites W1972303536 @default.
- W1982666967 cites W1976123250 @default.
- W1982666967 cites W1981351144 @default.
- W1982666967 cites W1998663807 @default.
- W1982666967 cites W2000220490 @default.
- W1982666967 cites W2000971601 @default.
- W1982666967 cites W2013544460 @default.
- W1982666967 cites W2014588679 @default.
- W1982666967 cites W2025441921 @default.
- W1982666967 cites W2028964952 @default.
- W1982666967 cites W2040519568 @default.
- W1982666967 cites W2045236185 @default.
- W1982666967 cites W2050875729 @default.
- W1982666967 cites W2089249230 @default.
- W1982666967 cites W2105851213 @default.
- W1982666967 cites W2119048840 @default.
- W1982666967 cites W2148805136 @default.
- W1982666967 cites W2167797847 @default.
- W1982666967 cites W36853749 @default.
- W1982666967 doi "https://doi.org/10.1002/(sici)1098-2299(199802)43:2<109::aid-ddr4>3.0.co;2-o" @default.
- W1982666967 hasPublicationYear "1998" @default.
- W1982666967 type Work @default.
- W1982666967 sameAs 1982666967 @default.
- W1982666967 citedByCount "14" @default.
- W1982666967 countsByYear W19826669672012 @default.
- W1982666967 crossrefType "journal-article" @default.
- W1982666967 hasAuthorship W1982666967A5002605219 @default.
- W1982666967 hasAuthorship W1982666967A5011289494 @default.
- W1982666967 hasAuthorship W1982666967A5022440764 @default.
- W1982666967 hasAuthorship W1982666967A5034648363 @default.
- W1982666967 hasConcept C104317684 @default.
- W1982666967 hasConcept C121332964 @default.
- W1982666967 hasConcept C129312508 @default.
- W1982666967 hasConcept C153911025 @default.
- W1982666967 hasConcept C185592680 @default.
- W1982666967 hasConcept C2779186596 @default.
- W1982666967 hasConcept C2781440490 @default.
- W1982666967 hasConcept C43617362 @default.
- W1982666967 hasConcept C51323132 @default.
- W1982666967 hasConcept C552990157 @default.
- W1982666967 hasConcept C55493867 @default.
- W1982666967 hasConcept C62520636 @default.
- W1982666967 hasConcept C82381507 @default.
- W1982666967 hasConcept C86803240 @default.
- W1982666967 hasConcept C91881484 @default.
- W1982666967 hasConcept C94581717 @default.
- W1982666967 hasConceptScore W1982666967C104317684 @default.
- W1982666967 hasConceptScore W1982666967C121332964 @default.
- W1982666967 hasConceptScore W1982666967C129312508 @default.
- W1982666967 hasConceptScore W1982666967C153911025 @default.
- W1982666967 hasConceptScore W1982666967C185592680 @default.
- W1982666967 hasConceptScore W1982666967C2779186596 @default.
- W1982666967 hasConceptScore W1982666967C2781440490 @default.
- W1982666967 hasConceptScore W1982666967C43617362 @default.
- W1982666967 hasConceptScore W1982666967C51323132 @default.
- W1982666967 hasConceptScore W1982666967C552990157 @default.
- W1982666967 hasConceptScore W1982666967C55493867 @default.
- W1982666967 hasConceptScore W1982666967C62520636 @default.
- W1982666967 hasConceptScore W1982666967C82381507 @default.
- W1982666967 hasConceptScore W1982666967C86803240 @default.
- W1982666967 hasConceptScore W1982666967C91881484 @default.
- W1982666967 hasConceptScore W1982666967C94581717 @default.
- W1982666967 hasIssue "2" @default.
- W1982666967 hasLocation W19826669671 @default.
- W1982666967 hasOpenAccess W1982666967 @default.
- W1982666967 hasPrimaryLocation W19826669671 @default.
- W1982666967 hasRelatedWork W1982666967 @default.
- W1982666967 hasRelatedWork W2023165267 @default.
- W1982666967 hasRelatedWork W2064400673 @default.
- W1982666967 hasRelatedWork W2073865488 @default.
- W1982666967 hasRelatedWork W2081781149 @default.
- W1982666967 hasRelatedWork W2098695343 @default.
- W1982666967 hasRelatedWork W2118389104 @default.
- W1982666967 hasRelatedWork W2351765653 @default.
- W1982666967 hasRelatedWork W2474680186 @default.
- W1982666967 hasRelatedWork W2960360023 @default.
- W1982666967 hasVolume "43" @default.
- W1982666967 isParatext "false" @default.
- W1982666967 isRetracted "false" @default.
- W1982666967 magId "1982666967" @default.
- W1982666967 workType "article" @default.