Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982685000> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1982685000 endingPage "222" @default.
- W1982685000 startingPage "213" @default.
- W1982685000 abstract "Nowhere is the record of receptor evolution more accessible than in the organization of the 19 vertebrate genes coding for subunits of the major inhibitory neurotransmitter receptor in the central nervous system, the gamma-aminobutyric acid receptor (GABAAR). Co-expression of alpha, beta, and gamma subunit genes is necessary for the formation of a GABAAR that is potentiated by widely used anxiolytics, anticonvulsants, and hypnotics. The identification of alpha, beta, and gamma genes on chromosomes 4, 5, and 15 suggests that co-localization of a gamma gene with an alpha and beta may be important for brain function. We have now directly examined the organization of GABAAR subunit genes on human chromosomes. Estimates of physical distance using in situ hybridization to cells in interphase, and gene localization using hybridization to cells in metaphase demonstrate the existence of beta-alpha-alpha-gamma gene clusters in cytogenetic bands on chromosomes 4(p12) and 5(q34). Sequencing of PAC clones establishes intercluster conservation of a unique head-to-head configuration for alpha and beta genes on chromosomes 4, 5, and 15. Remarkably, phylogenetic tree analysis predicts the existence of a beta-alpha-gamma ancestral gene cluster in which internal duplication of an ancestral alpha was followed by cluster duplication, resulting in the relative chromosomal positions of modern GABAAR subunit genes in the human genome." @default.
- W1982685000 created "2016-06-24" @default.
- W1982685000 creator A5072309242 @default.
- W1982685000 date "1999-02-01" @default.
- W1982685000 modified "2023-10-13" @default.
- W1982685000 title "Evolution of GABAA receptor diversity in the human genome" @default.
- W1982685000 cites W1523929824 @default.
- W1982685000 cites W1524203275 @default.
- W1982685000 cites W1549549440 @default.
- W1982685000 cites W1551663317 @default.
- W1982685000 cites W180574079 @default.
- W1982685000 cites W1999154941 @default.
- W1982685000 cites W1999485170 @default.
- W1982685000 cites W2003790129 @default.
- W1982685000 cites W2004010919 @default.
- W1982685000 cites W2011218093 @default.
- W1982685000 cites W2012687896 @default.
- W1982685000 cites W2016167864 @default.
- W1982685000 cites W2023468172 @default.
- W1982685000 cites W2025048783 @default.
- W1982685000 cites W2027867510 @default.
- W1982685000 cites W2039813353 @default.
- W1982685000 cites W2044702390 @default.
- W1982685000 cites W2057457677 @default.
- W1982685000 cites W2059208153 @default.
- W1982685000 cites W2059812096 @default.
- W1982685000 cites W2071709232 @default.
- W1982685000 cites W2081160811 @default.
- W1982685000 cites W2093099942 @default.
- W1982685000 cites W2106593900 @default.
- W1982685000 cites W2125188380 @default.
- W1982685000 cites W2138270253 @default.
- W1982685000 cites W2403713566 @default.
- W1982685000 cites W4317524510 @default.
- W1982685000 doi "https://doi.org/10.1016/s0378-1119(98)00594-0" @default.
- W1982685000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10023064" @default.
- W1982685000 hasPublicationYear "1999" @default.
- W1982685000 type Work @default.
- W1982685000 sameAs 1982685000 @default.
- W1982685000 citedByCount "65" @default.
- W1982685000 countsByYear W19826850002012 @default.
- W1982685000 countsByYear W19826850002013 @default.
- W1982685000 countsByYear W19826850002014 @default.
- W1982685000 countsByYear W19826850002015 @default.
- W1982685000 countsByYear W19826850002016 @default.
- W1982685000 countsByYear W19826850002017 @default.
- W1982685000 countsByYear W19826850002019 @default.
- W1982685000 countsByYear W19826850002020 @default.
- W1982685000 countsByYear W19826850002021 @default.
- W1982685000 countsByYear W19826850002023 @default.
- W1982685000 crossrefType "journal-article" @default.
- W1982685000 hasAuthorship W1982685000A5072309242 @default.
- W1982685000 hasConcept C104292427 @default.
- W1982685000 hasConcept C104317684 @default.
- W1982685000 hasConcept C141231307 @default.
- W1982685000 hasConcept C30481170 @default.
- W1982685000 hasConcept C36069631 @default.
- W1982685000 hasConcept C36857842 @default.
- W1982685000 hasConcept C54355233 @default.
- W1982685000 hasConcept C5911399 @default.
- W1982685000 hasConcept C70278784 @default.
- W1982685000 hasConcept C7602840 @default.
- W1982685000 hasConcept C86803240 @default.
- W1982685000 hasConceptScore W1982685000C104292427 @default.
- W1982685000 hasConceptScore W1982685000C104317684 @default.
- W1982685000 hasConceptScore W1982685000C141231307 @default.
- W1982685000 hasConceptScore W1982685000C30481170 @default.
- W1982685000 hasConceptScore W1982685000C36069631 @default.
- W1982685000 hasConceptScore W1982685000C36857842 @default.
- W1982685000 hasConceptScore W1982685000C54355233 @default.
- W1982685000 hasConceptScore W1982685000C5911399 @default.
- W1982685000 hasConceptScore W1982685000C70278784 @default.
- W1982685000 hasConceptScore W1982685000C7602840 @default.
- W1982685000 hasConceptScore W1982685000C86803240 @default.
- W1982685000 hasIssue "2" @default.
- W1982685000 hasLocation W19826850001 @default.
- W1982685000 hasLocation W19826850002 @default.
- W1982685000 hasOpenAccess W1982685000 @default.
- W1982685000 hasPrimaryLocation W19826850001 @default.
- W1982685000 hasRelatedWork W1914610732 @default.
- W1982685000 hasRelatedWork W1970221653 @default.
- W1982685000 hasRelatedWork W2002623332 @default.
- W1982685000 hasRelatedWork W2050456981 @default.
- W1982685000 hasRelatedWork W2094430808 @default.
- W1982685000 hasRelatedWork W2168252161 @default.
- W1982685000 hasRelatedWork W2999254484 @default.
- W1982685000 hasRelatedWork W3040603050 @default.
- W1982685000 hasRelatedWork W3126460685 @default.
- W1982685000 hasRelatedWork W4378782348 @default.
- W1982685000 hasVolume "227" @default.
- W1982685000 isParatext "false" @default.
- W1982685000 isRetracted "false" @default.
- W1982685000 magId "1982685000" @default.
- W1982685000 workType "article" @default.