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• W1982694720 abstract "1.1 Clinical and pathological aspects of Parkinson’s disease Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting millions of people worldwide (Dorsey, Constantinescu et al. 2007). While some cases of familial PD have been reported, the etiology of most cases is still unknown. Significant progress in understanding the pathophysiology of PD has been made from genetic and epidemiologic studies that have implicated defects in a few key biological processes as potential final common pathological pathways. PD is a progressive motor disorder characterized by death of dopaminergic neurons in the region of the brain called the substantia nigra pars compacta although other areas of the central and peripheral nervous system are involved (Braak, Del Tredici et al. 2003). The loss of dopaminergic neurons in PD leads to motor symptoms that include akinesia (inability to initiate movement), bradykinesia (slowness of movement), resting tremor, and balance problems. Non-motor symptoms can include cognitive impairments, mood disturbances, sleep dysfunction, gastrointestinal problems, and dysautonomia. PD is a progressive disorder and despite several effective therapies that treat many of the symptoms, there are no treatments that alter disease progression. Uncovering the causes of PD is likely necessary to find effective disease modifying therapies. The pathological hallmark of PD is the presence of Lewy bodies, which are cytosolic inclusions with several molecular components although -synuclein (-syn) is the predominant protein (Spillantini, Schmidt et al. 1997). Lewy bodies also contain ubiquitin, a polypeptide that targets proteins to the ubiquitin proteasome system (UPS) for degradation." @default.
• W1982694720 created "2016-06-24" @default.
• W1982694720 creator A5016423162 @default.
• W1982694720 creator A5023435959 @default.
• W1982694720 date "2011-09-12" @default.
• W1982694720 modified "2023-09-26" @default.
• W1982694720 title "Pesticides and Parkinson’s Disease" @default.
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