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• W1982698061 abstract "DACA, also known as XR5000, is an acridine derivative active against both topoisomerase I and II. In this phase I study, DACA was given as a 3-h intravenous infusion on 3 successive days, repeated every 3 weeks. A total of 41 patients were treated at 11 dose levels between 9 mg m–2 d–1 and the maximum tolerated dose of 800 mg m–2 day–1. The commonest, and dose-limiting, toxicity was pain in the infusion arm. One patient given DACA through a central venous catheter experienced chest pain with transient electrocardiogram changes, but no evidence of myocardial infarction. At the highest dose levels, several patients also experienced flushing, pain and paraesthesia around the mouth, eyes and nose and a feeling of agitation. Other side-effects, such as nausea and vomiting, myelosuppression, stomatitis and alopecia, were uncommon. There was one minor response but no objective responses. DACA pharmacokinetics were linear and did not differ between days 1 and 3. The pattern of toxicity seen with DACA is unusual and appears related to the mode of delivery. It is possible that higher doses of DACA could be administered using a different schedule of administration." @default.
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• W1982698061 date "1999-07-09" @default.
• W1982698061 modified "2023-10-10" @default.
• W1982698061 title "Phase I and pharmacokinetic study of DACA (XR5000): a novel inhibitor of topoisomerase I and II" @default.
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• W1982698061 doi "https://doi.org/10.1038/sj.bjc.6690598" @default.
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