Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982751982> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1982751982 endingPage "69" @default.
- W1982751982 startingPage "61" @default.
- W1982751982 abstract "We studied on the role of an intramolecular disulfide bond of KF4939 in its anti-platelet actions by using rabbit platelets. The inhibitions of aggregation of platelet-rich plasma (PRP) and washed platelets, and of malondialdehyde production in thrombin-stimulated platelets by KF4939 were counteracted by pretreatment with sulfhydryl compounds, glutathione, 1-cysteine and dithiothreitol. A reduced compound of KF4939 (Red-KF4939) showed nearly equal anti-aggregating activities to those of KF4939 in PRP, it, however, showed low activities to inhibit platelet aggregation and thrombin -stimulated malondialdehyde production in washed platelet suspensions. In addition, the anti-aggregating action of Red-KF4939 was counteracted by pretreatment with sulfhydryl compounds, similarly to that of KF4939. Furthermore, when platelets were treated with KF4939, a significant decrease of protein-bound sulfhydryl groups was observed. We may conclude from these results that the intramolecular disulfide bond plays an essential role in anti-platelet actions of KF4939 and the interaction of the disulfide bond with protein-bound sulfhydryl groups may be involved in the mechanism of anti-platelet actions of KF4939." @default.
- W1982751982 created "2016-06-24" @default.
- W1982751982 creator A5033216757 @default.
- W1982751982 creator A5047678006 @default.
- W1982751982 creator A5069511654 @default.
- W1982751982 creator A5089761965 @default.
- W1982751982 date "1985-04-01" @default.
- W1982751982 modified "2023-10-16" @default.
- W1982751982 title "Involvement of disulfide-sulfhydryl interaction in anti-platelet actions of KF4939" @default.
- W1982751982 cites W11482174 @default.
- W1982751982 cites W1984635003 @default.
- W1982751982 cites W1985779245 @default.
- W1982751982 cites W2004828037 @default.
- W1982751982 cites W2015031819 @default.
- W1982751982 cites W2046351446 @default.
- W1982751982 cites W2084263705 @default.
- W1982751982 cites W2266929960 @default.
- W1982751982 cites W2415040401 @default.
- W1982751982 cites W302960420 @default.
- W1982751982 doi "https://doi.org/10.1016/0049-3848(85)90007-6" @default.
- W1982751982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4002199" @default.
- W1982751982 hasPublicationYear "1985" @default.
- W1982751982 type Work @default.
- W1982751982 sameAs 1982751982 @default.
- W1982751982 citedByCount "6" @default.
- W1982751982 countsByYear W19827519822019 @default.
- W1982751982 countsByYear W19827519822020 @default.
- W1982751982 crossrefType "journal-article" @default.
- W1982751982 hasAuthorship W1982751982A5033216757 @default.
- W1982751982 hasAuthorship W1982751982A5047678006 @default.
- W1982751982 hasAuthorship W1982751982A5069511654 @default.
- W1982751982 hasAuthorship W1982751982A5089761965 @default.
- W1982751982 hasConcept C126322002 @default.
- W1982751982 hasConcept C181199279 @default.
- W1982751982 hasConcept C185592680 @default.
- W1982751982 hasConcept C27256138 @default.
- W1982751982 hasConcept C2777292125 @default.
- W1982751982 hasConcept C2777824588 @default.
- W1982751982 hasConcept C2778004101 @default.
- W1982751982 hasConcept C2778401633 @default.
- W1982751982 hasConcept C2779201268 @default.
- W1982751982 hasConcept C2781324293 @default.
- W1982751982 hasConcept C538909803 @default.
- W1982751982 hasConcept C55493867 @default.
- W1982751982 hasConcept C71240020 @default.
- W1982751982 hasConcept C71924100 @default.
- W1982751982 hasConcept C75079739 @default.
- W1982751982 hasConcept C89560881 @default.
- W1982751982 hasConceptScore W1982751982C126322002 @default.
- W1982751982 hasConceptScore W1982751982C181199279 @default.
- W1982751982 hasConceptScore W1982751982C185592680 @default.
- W1982751982 hasConceptScore W1982751982C27256138 @default.
- W1982751982 hasConceptScore W1982751982C2777292125 @default.
- W1982751982 hasConceptScore W1982751982C2777824588 @default.
- W1982751982 hasConceptScore W1982751982C2778004101 @default.
- W1982751982 hasConceptScore W1982751982C2778401633 @default.
- W1982751982 hasConceptScore W1982751982C2779201268 @default.
- W1982751982 hasConceptScore W1982751982C2781324293 @default.
- W1982751982 hasConceptScore W1982751982C538909803 @default.
- W1982751982 hasConceptScore W1982751982C55493867 @default.
- W1982751982 hasConceptScore W1982751982C71240020 @default.
- W1982751982 hasConceptScore W1982751982C71924100 @default.
- W1982751982 hasConceptScore W1982751982C75079739 @default.
- W1982751982 hasConceptScore W1982751982C89560881 @default.
- W1982751982 hasIssue "1" @default.
- W1982751982 hasLocation W19827519821 @default.
- W1982751982 hasLocation W19827519822 @default.
- W1982751982 hasOpenAccess W1982751982 @default.
- W1982751982 hasPrimaryLocation W19827519821 @default.
- W1982751982 hasRelatedWork W1982751982 @default.
- W1982751982 hasRelatedWork W2015816601 @default.
- W1982751982 hasRelatedWork W2051259561 @default.
- W1982751982 hasRelatedWork W2060987419 @default.
- W1982751982 hasRelatedWork W2069826186 @default.
- W1982751982 hasRelatedWork W2074960867 @default.
- W1982751982 hasRelatedWork W2161426711 @default.
- W1982751982 hasRelatedWork W2278829643 @default.
- W1982751982 hasRelatedWork W2607704937 @default.
- W1982751982 hasRelatedWork W965553944 @default.
- W1982751982 hasVolume "38" @default.
- W1982751982 isParatext "false" @default.
- W1982751982 isRetracted "false" @default.
- W1982751982 magId "1982751982" @default.
- W1982751982 workType "article" @default.