Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982762466> ?p ?o ?g. }
- W1982762466 abstract "MiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common targets. In one cluster containing three miRNAs, miR-612, miR-661 and miR-940, the annotated functions of the co-regulated genes suggested a role in small GTPase signalling. Although the three members of this cluster targeted the same subset of predicted genes, we showed that their overexpression impacted cell fates differently. miR-661 demonstrated enhanced phosphorylation of myosin II and an increase in cell invasion, indicating a possible oncogenic miRNA. On the contrary, miR-612 and miR-940 inhibit phosphorylation of myosin II and cell invasion. Finally, expression profiling in human breast tissues showed that miR-940 was consistently downregulated in breast cancer tissues." @default.
- W1982762466 created "2016-06-24" @default.
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- W1982762466 date "2015-02-12" @default.
- W1982762466 modified "2023-10-06" @default.
- W1982762466 title "A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator" @default.
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- W1982762466 doi "https://doi.org/10.1038/srep08336" @default.
- W1982762466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5389139" @default.
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- W1982762466 hasPublicationYear "2015" @default.
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