FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982773400> ?p ?o ?g. }

• W1982773400 endingPage "568" @default.
• W1982773400 startingPage "555" @default.
• W1982773400 abstract "The bacterial metalloregulator MerR is the index case of an eponymous family of regulatory proteins, which controls the transcription of a set of genes (the mer operon) conferring mercury resistance in many bacteria. Homodimeric MerR represses transcription in the absence of mercury and activates transcription upon Hg(II) binding. Here, the average structures of the apo and Hg(II)-bound forms of MerR in aqueous solution are examined using small-angle X-ray scattering, indicating an extended conformation of the metal-bound protein and revealing the existence of a novel compact conformation in the absence of Hg(II). Molecular dynamics (MD) simulations are performed to characterize the conformational dynamics of the Hg(II)-bound form. In both small-angle X-ray scattering and MD, the average torsional angle between DNA-binding domains is approximately 65 degrees. Furthermore, in MD, interdomain motions on a timescale of approximately 10 ns involving large-amplitude (approximately 20 A) domain opening-and-closing, coupled to approximately 40 degrees variations of interdomain torsional angle, are revealed. This correlated domain motion may propagate allosteric changes from the metal-binding site to the DNA-binding site while maintaining DNA contacts required to initiate DNA underwinding." @default.
• W1982773400 created "2016-06-24" @default.
• W1982773400 creator A5007867266 @default.
• W1982773400 creator A5018366869 @default.
• W1982773400 creator A5030502518 @default.
• W1982773400 creator A5037417242 @default.
• W1982773400 creator A5042897875 @default.
• W1982773400 creator A5044456630 @default.
• W1982773400 creator A5068718671 @default.
• W1982773400 creator A5087737425 @default.
• W1982773400 date "2010-05-01" @default.
• W1982773400 modified "2023-10-01" @default.
• W1982773400 title "Structure and Conformational Dynamics of the Metalloregulator MerR upon Binding of Hg(II)" @default.
• W1982773400 cites W1554026413 @default.
• W1982773400 cites W1586917242 @default.
• W1982773400 cites W1601958919 @default.
• W1982773400 cites W1745021804 @default.
• W1982773400 cites W1847952945 @default.
• W1982773400 cites W1942379186 @default.
• W1982773400 cites W1976499671 @default.
• W1982773400 cites W1977038370 @default.
• W1982773400 cites W1977327628 @default.
• W1982773400 cites W1978874279 @default.
• W1982773400 cites W1980140051 @default.
• W1982773400 cites W1982126789 @default.
• W1982773400 cites W1982418026 @default.
• W1982773400 cites W1989778057 @default.
• W1982773400 cites W1991238097 @default.
• W1982773400 cites W1991357892 @default.
• W1982773400 cites W1995732138 @default.
• W1982773400 cites W1997041104 @default.
• W1982773400 cites W1999570631 @default.
• W1982773400 cites W2001728380 @default.
• W1982773400 cites W2003660859 @default.
• W1982773400 cites W2005487874 @default.
• W1982773400 cites W2007107624 @default.
• W1982773400 cites W2012072946 @default.
• W1982773400 cites W2013264804 @default.
• W1982773400 cites W2014247667 @default.
• W1982773400 cites W2014828918 @default.
• W1982773400 cites W2016567958 @default.
• W1982773400 cites W2020081833 @default.
• W1982773400 cites W2021978625 @default.
• W1982773400 cites W2022571490 @default.
• W1982773400 cites W2025398142 @default.
• W1982773400 cites W2027408247 @default.
• W1982773400 cites W2027662902 @default.
• W1982773400 cites W2029667189 @default.
• W1982773400 cites W2030658423 @default.
• W1982773400 cites W2038758364 @default.
• W1982773400 cites W2039243189 @default.
• W1982773400 cites W2050091361 @default.
• W1982773400 cites W2055043387 @default.
• W1982773400 cites W2060384825 @default.
• W1982773400 cites W2060809301 @default.
• W1982773400 cites W2062840916 @default.
• W1982773400 cites W2062889586 @default.
• W1982773400 cites W2066088601 @default.
• W1982773400 cites W2067174909 @default.
• W1982773400 cites W2068143689 @default.
• W1982773400 cites W2070630890 @default.
• W1982773400 cites W2071238919 @default.
• W1982773400 cites W2074228244 @default.
• W1982773400 cites W2079461094 @default.
• W1982773400 cites W2080131435 @default.
• W1982773400 cites W2106140689 @default.
• W1982773400 cites W2107921073 @default.
• W1982773400 cites W2122339645 @default.
• W1982773400 cites W2131228723 @default.
• W1982773400 cites W2136620829 @default.
• W1982773400 cites W2149885731 @default.
• W1982773400 cites W2150981663 @default.
• W1982773400 cites W2161714667 @default.
• W1982773400 cites W2162166182 @default.
• W1982773400 cites W2167506192 @default.
• W1982773400 cites W2169620403 @default.
• W1982773400 cites W3022663845 @default.
• W1982773400 doi "https://doi.org/10.1016/j.jmb.2010.03.020" @default.
• W1982773400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20303978" @default.
• W1982773400 hasPublicationYear "2010" @default.
• W1982773400 type Work @default.
• W1982773400 sameAs 1982773400 @default.
• W1982773400 citedByCount "35" @default.
• W1982773400 countsByYear W19827734002012 @default.
• W1982773400 countsByYear W19827734002013 @default.
• W1982773400 countsByYear W19827734002014 @default.
• W1982773400 countsByYear W19827734002015 @default.
• W1982773400 countsByYear W19827734002016 @default.
• W1982773400 countsByYear W19827734002017 @default.
• W1982773400 countsByYear W19827734002018 @default.
• W1982773400 countsByYear W19827734002019 @default.
• W1982773400 countsByYear W19827734002020 @default.
• W1982773400 countsByYear W19827734002021 @default.
• W1982773400 countsByYear W19827734002022 @default.
• W1982773400 countsByYear W19827734002023 @default.
• W1982773400 crossrefType "journal-article" @default.
• W1982773400 hasAuthorship W1982773400A5007867266 @default.
• W1982773400 hasAuthorship W1982773400A5018366869 @default.

• next