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- W1982778642 abstract "The Drosophila fushi tarazu (ftz) upstream element is an enhancer-like element that is required for the correct expression of ftz in developing embryos and that directs transcription from a minimal promoter in a ftz-like seven-striped pattern. Using a deletion analysis, we have identified several independent cis-regulatory elements in the upstream element. A distal enhancer directs fusion gene expression in seven stripes primarily in the mesoderm. A more complex proximal enhancer contains a mesodermally active element and a second element with which it interacts to generate seven stripes in the ectoderm. Striped expression directed by each enhancer is ftz-dependent, and each contains binding sites for purified ftz homeo domain. We suggest that ftz protein acts in combination with germ layer-restricted transcription factors directly and positively to regulate the transcription of its own gene." @default.
- W1982778642 created "2016-06-24" @default.
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- W1982778642 date "1990-07-01" @default.
- W1982778642 modified "2023-10-18" @default.
- W1982778642 title "Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated." @default.
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- W1982778642 doi "https://doi.org/10.1101/gad.4.7.1224" @default.
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