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• W1982781171 endingPage "9706" @default.
• W1982781171 startingPage "9693" @default.
• W1982781171 abstract "ABSTRACT Human immunodeficiency virus type 1 (HIV-1) transcription is subject to substantial fluctuation during the viral life cycle. Due to the low frequencies of HIV-1-infected cells, and because latently and productively infected cells collocate in vivo, little quantitative knowledge has been attained about the range of in vivo HIV-1 transcription in peripheral blood mononuclear cells (PBMC). By combining cell sorting, terminal dilution of intact cells, and highly sensitive, patient-specific PCR assays, we divided PBMC obtained from HIV-1-infected patients according to their degree of viral transcription activity and their cellular phenotype. Regardless of a patient's treatment status, the bulk of infected cells exhibited a CD4 + phenotype but transcribed HIV-1 provirus at low levels, presumably insufficient for virion production. Furthermore, the expression of activation markers on the surface of these CD4 + T lymphocytes showed little or no association with enhancement of viral transcription. In contrast, HIV-infected T lymphocytes of a CD4 − /CD8 − phenotype, occurring exclusively in untreated patients, exhibited elevated viral transcription rates. This cell type harbored a substantial proportion of all HIV RNA + cells and intracellular viral RNAs and the majority of cell-associated virus particles. In conjunction with the observation that the HIV quasispecies in CD4 + and CD4 − /CD8 − T cells were phylogenetically closely related, these findings provide evidence that CD4 expression is downmodulated during the transition to productive infection in vivo. The abundance of viral RNA in CD4 − /CD8 − T cells from viremic patients and the almost complete absence of viral DNA and RNA in this cell type during antiretroviral treatment identify HIV + CD4 − /CD8 T cells as the major cell type harboring productive infection in peripheral blood." @default.
• W1982781171 created "2016-06-24" @default.
• W1982781171 creator A5017998451 @default.
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• W1982781171 creator A5086552318 @default.
• W1982781171 creator A5088187599 @default.
• W1982781171 date "2007-09-15" @default.
• W1982781171 modified "2023-09-23" @default.
• W1982781171 title "Productive Human Immunodeficiency Virus Type 1 Infection in Peripheral Blood Predominantly Takes Place in CD4/CD8 Double-Negative T Lymphocytes" @default.
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• W1982781171 doi "https://doi.org/10.1128/jvi.00492-07" @default.
• W1982781171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045436" @default.
• W1982781171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17609262" @default.
• W1982781171 hasPublicationYear "2007" @default.
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