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• W1982781199 abstract "Abstract Immune parameters were examined in 188 patients who were exposed for more than 6 mo to pentachlorophenol-containing pesticides. Blood levels of pentachlorophenol, lymphocyte subpopulations, in-vitro responses to mitogenic and allogeneic stimulation, plasma neopterin levels, and plasma cytokine and cytokine receptor levels were determined. Impaired in-vitro lymphocyte stimulation responses were impaired in 65% of the patients. The likelihood of impaired lymphocyte stimulation increased significantly with levels of pentachlorophenol that exceeded 10 μl/l (p < .05). Patients who had high blood levels of pentachlorophenol and abnormal lymphocyte stimulation also had increased proportions of blood monocytes in blood (p < .05), as well as increased IL-8 serum levels (p < .02). Eleven patients who had abnormal mitogen stimulation experienced decreased CD4/CD8 ratios of < 1.0; 5 of these patients had decreased CD4+ lymphocyte counts of < 500/μl, and 3 patients had increased plasma neopterin of < 15 nmol/l. These results indicate that increased levels of pentachlorophenol in blood can lead to severe T lymphocyte dysfunction." @default.
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• W1982781199 date "1995-08-01" @default.
• W1982781199 modified "2023-09-23" @default.
• W1982781199 title "Impaired In-Vitro Lymphocyte Responses in Patients with Elevated Pentachlorophenol (PCP) Blood Levels" @default.
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• W1982781199 doi "https://doi.org/10.1080/00039896.1995.9935956" @default.
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