FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982783009> ?p ?o ?g. }

• W1982783009 endingPage "5259" @default.
• W1982783009 startingPage "5259" @default.
• W1982783009 abstract "Matrix metalloproteinase (MMP)-mediated turnover of extracellular matrix (ECM) affects outflow resistance in the uveoscleral pathway. The balance of MMPs and tissue inhibitors of metalloproteinases (TIMPs) governs the rate of ECM turnover in many tissues. The hypothesis was that a differential effect on MMPs and TIMPs in ciliary body smooth muscle (CBSM) cells would relate to the relative intraocular pressure-lowering effectiveness of the prostaglandin analogues (PGAs) bimatoprost, latanoprost, and unoprostone.Human CBSM cells isolated from donor corneoscleral rims were incubated for 24 hours with control (0.015% ethanol in DMEM) or the free acid forms of bimatoprost (0.01 or 0.1 microg/mL), latanoprost (0.03 or 0.3 microg/mL), or unoprostone (0.145 or 1.45 microg/mL). Western blot analysis determined the relative protein concentrations of MMP-1, -2, -3. -9, and -24 as well as TIMP-1 through -4. Zymography measured the relative activity levels of MMP-1, -2, -3, and -9.All PGAs increased MMP-1, -3, and -9. Bimatoprost and latanoprost did not change MMP-2. Unoprostone decreased MMP-2 (21% +/- 3%). On zymography, MMP-1 and -2 did not change. Bimatoprost and latanoprost increased MMP-9 activity by 75% +/- 27% and 75% +/- 24%, respectively. MMP-3 activity was not detected on zymography. All PGAs increased TIMP-3, but only unoprostone increased TIMPs1 and -4 by 100% +/- 20% and 61% +/- 11%, respectively. TIMP-2 was unchanged by bimatoprost and latanoprost, but decreased by unoprostone (35% +/- 8%).Decreased MMP-2 with concurrent increases of TIMP-1 and -4 by unoprostone may explain the lower clinical efficacy of unoprostone. The MMP/TIMP balance relates to the observed intraocular pressure-lowering effectiveness in clinical studies with PGAs." @default.
• W1982783009 created "2016-06-24" @default.
• W1982783009 creator A5008388975 @default.
• W1982783009 creator A5020310938 @default.
• W1982783009 creator A5064047026 @default.
• W1982783009 date "2009-11-01" @default.
• W1982783009 modified "2023-09-26" @default.
• W1982783009 title "Effect of Bimatoprost, Latanoprost, and Unoprostone on Matrix Metalloproteinases and Their Inhibitors in Human Ciliary Body Smooth Muscle Cells" @default.
• W1982783009 cites W104777046 @default.
• W1982783009 cites W1527689251 @default.
• W1982783009 cites W1549954866 @default.
• W1982783009 cites W1551688761 @default.
• W1982783009 cites W1711622231 @default.
• W1982783009 cites W1810830878 @default.
• W1982783009 cites W187900115 @default.
• W1982783009 cites W196236791 @default.
• W1982783009 cites W1964320159 @default.
• W1982783009 cites W1969653655 @default.
• W1982783009 cites W1969866031 @default.
• W1982783009 cites W1977653161 @default.
• W1982783009 cites W1977918153 @default.
• W1982783009 cites W1985221337 @default.
• W1982783009 cites W1985689227 @default.
• W1982783009 cites W1987931137 @default.
• W1982783009 cites W1990234206 @default.
• W1982783009 cites W1992093601 @default.
• W1982783009 cites W1997522892 @default.
• W1982783009 cites W2000085293 @default.
• W1982783009 cites W2001622302 @default.
• W1982783009 cites W2011300791 @default.
• W1982783009 cites W2014817651 @default.
• W1982783009 cites W2016305812 @default.
• W1982783009 cites W2018207692 @default.
• W1982783009 cites W2024597485 @default.
• W1982783009 cites W2026749013 @default.
• W1982783009 cites W2027328967 @default.
• W1982783009 cites W2027629652 @default.
• W1982783009 cites W2032099355 @default.
• W1982783009 cites W2032545195 @default.
• W1982783009 cites W2033780254 @default.
• W1982783009 cites W2040322156 @default.
• W1982783009 cites W2045012349 @default.
• W1982783009 cites W2045804469 @default.
• W1982783009 cites W2045830688 @default.
• W1982783009 cites W2048120869 @default.
• W1982783009 cites W2048803544 @default.
• W1982783009 cites W2049784117 @default.
• W1982783009 cites W2058142957 @default.
• W1982783009 cites W2059589670 @default.
• W1982783009 cites W2060032838 @default.
• W1982783009 cites W2060654250 @default.
• W1982783009 cites W2062768670 @default.
• W1982783009 cites W2063560538 @default.
• W1982783009 cites W2064925055 @default.
• W1982783009 cites W2064944758 @default.
• W1982783009 cites W2065486056 @default.
• W1982783009 cites W206738081 @default.
• W1982783009 cites W2070012048 @default.
• W1982783009 cites W2071605868 @default.
• W1982783009 cites W2076718353 @default.
• W1982783009 cites W2078997223 @default.
• W1982783009 cites W2080504583 @default.
• W1982783009 cites W2083699796 @default.
• W1982783009 cites W2084799204 @default.
• W1982783009 cites W2088223428 @default.
• W1982783009 cites W2093394571 @default.
• W1982783009 cites W2103131763 @default.
• W1982783009 cites W2107775650 @default.
• W1982783009 cites W2124657193 @default.
• W1982783009 cites W2143421522 @default.
• W1982783009 cites W2143908548 @default.
• W1982783009 cites W2144015336 @default.
• W1982783009 cites W2147632031 @default.
• W1982783009 cites W2223422698 @default.
• W1982783009 cites W2416586448 @default.
• W1982783009 cites W2466503896 @default.
• W1982783009 cites W70565427 @default.
• W1982783009 cites W71754498 @default.
• W1982783009 cites W90697117 @default.
• W1982783009 doi "https://doi.org/10.1167/iovs.08-3356" @default.
• W1982783009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19443729" @default.
• W1982783009 hasPublicationYear "2009" @default.
• W1982783009 type Work @default.
• W1982783009 sameAs 1982783009 @default.
• W1982783009 citedByCount "37" @default.
• W1982783009 countsByYear W19827830092012 @default.
• W1982783009 countsByYear W19827830092013 @default.
• W1982783009 countsByYear W19827830092014 @default.
• W1982783009 countsByYear W19827830092015 @default.
• W1982783009 countsByYear W19827830092016 @default.
• W1982783009 countsByYear W19827830092017 @default.
• W1982783009 countsByYear W19827830092018 @default.
• W1982783009 countsByYear W19827830092019 @default.
• W1982783009 countsByYear W19827830092020 @default.
• W1982783009 countsByYear W19827830092021 @default.
• W1982783009 countsByYear W19827830092022 @default.
• W1982783009 countsByYear W19827830092023 @default.
• W1982783009 crossrefType "journal-article" @default.

• next