FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982783526> ?p ?o ?g. }

• W1982783526 endingPage "77" @default.
• W1982783526 startingPage "71" @default.
• W1982783526 abstract "Cyclopentenone prostaglandins have been identified as potential neurotoxic agents in the setting of hypoxia-ischemia. Cyclooxygenase-2 (COX-2), the upstream enzyme responsible for prostaglandin production is upregulated following hypoxic-ischemic brain injury. However, the temporal production and concentration of cyclopentenone prostaglandins has not been described following global brain ischemia.MethodsGlobal brain ischemia was induced in rats by asphyxial cardiac arrest (ACA) followed by resuscitation. Rats were sacrificed between 24 h and 7 days following resuscitation and their brains removed. Western blot, immunohistochemistry, and mass spectroscopy were performed. A cohort of rats was pretreated with the COX-2 inhibitor SC58125.ResultsCOX-2 is induced in hippocampus at 24 h following ACA. Multiple prostaglandins, including cyclopentenone prostaglandin species, are increased in hippocampus as 24 h following ACA. Prostaglandin and cyclopentenone prostaglandin concentrations are returned to baseline at 3 and 7 days post-ischemia. The COX-2 inhibitor SC58125 completely abrogates the post-ischemic increase in prostaglandins and cyclopentenone prostaglandins.ConclusionsProstaglandins, including cyclopentenone prostaglandins, are increased in ischemic brain, peak at 24 h and can be attenuated by the COX-2 inhibitor SC58125. These data establish the presence of potentially neurotoxic cyclopentenone prostaglandins in post-ischemic brains, thus identifying a target and therapeutic window for neuroprotective therapies." @default.
• W1982783526 created "2016-06-24" @default.
• W1982783526 creator A5034980437 @default.
• W1982783526 creator A5048744992 @default.
• W1982783526 creator A5052871360 @default.
• W1982783526 creator A5059950155 @default.
• W1982783526 creator A5062540982 @default.
• W1982783526 creator A5062755212 @default.
• W1982783526 creator A5078008616 @default.
• W1982783526 creator A5088275272 @default.
• W1982783526 creator A5088664989 @default.
• W1982783526 date "2013-06-01" @default.
• W1982783526 modified "2023-10-03" @default.
• W1982783526 title "COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest" @default.
• W1982783526 cites W1529677119 @default.
• W1982783526 cites W1969428124 @default.
• W1982783526 cites W1979523972 @default.
• W1982783526 cites W1979700018 @default.
• W1982783526 cites W1980410293 @default.
• W1982783526 cites W1980908499 @default.
• W1982783526 cites W1993213847 @default.
• W1982783526 cites W1999894132 @default.
• W1982783526 cites W2006577697 @default.
• W1982783526 cites W2010027879 @default.
• W1982783526 cites W2016676102 @default.
• W1982783526 cites W2016904381 @default.
• W1982783526 cites W2017831280 @default.
• W1982783526 cites W2029019062 @default.
• W1982783526 cites W2029852623 @default.
• W1982783526 cites W2046892501 @default.
• W1982783526 cites W2050054515 @default.
• W1982783526 cites W2078232163 @default.
• W1982783526 cites W2091601828 @default.
• W1982783526 cites W2101736298 @default.
• W1982783526 cites W2145519598 @default.
• W1982783526 cites W2147874368 @default.
• W1982783526 cites W2153819462 @default.
• W1982783526 cites W2156675756 @default.
• W1982783526 cites W2962860949 @default.
• W1982783526 cites W4247315158 @default.
• W1982783526 doi "https://doi.org/10.1016/j.brainres.2013.04.029" @default.
• W1982783526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3681205" @default.
• W1982783526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23624225" @default.
• W1982783526 hasPublicationYear "2013" @default.
• W1982783526 type Work @default.
• W1982783526 sameAs 1982783526 @default.
• W1982783526 citedByCount "16" @default.
• W1982783526 countsByYear W19827835262013 @default.
• W1982783526 countsByYear W19827835262014 @default.
• W1982783526 countsByYear W19827835262015 @default.
• W1982783526 countsByYear W19827835262016 @default.
• W1982783526 countsByYear W19827835262017 @default.
• W1982783526 countsByYear W19827835262020 @default.
• W1982783526 countsByYear W19827835262021 @default.
• W1982783526 countsByYear W19827835262022 @default.
• W1982783526 crossrefType "journal-article" @default.
• W1982783526 hasAuthorship W1982783526A5034980437 @default.
• W1982783526 hasAuthorship W1982783526A5048744992 @default.
• W1982783526 hasAuthorship W1982783526A5052871360 @default.
• W1982783526 hasAuthorship W1982783526A5059950155 @default.
• W1982783526 hasAuthorship W1982783526A5062540982 @default.
• W1982783526 hasAuthorship W1982783526A5062755212 @default.
• W1982783526 hasAuthorship W1982783526A5078008616 @default.
• W1982783526 hasAuthorship W1982783526A5088275272 @default.
• W1982783526 hasAuthorship W1982783526A5088664989 @default.
• W1982783526 hasBestOaLocation W19827835262 @default.
• W1982783526 hasConcept C126322002 @default.
• W1982783526 hasConcept C134018914 @default.
• W1982783526 hasConcept C178790620 @default.
• W1982783526 hasConcept C181199279 @default.
• W1982783526 hasConcept C185592680 @default.
• W1982783526 hasConcept C25498285 @default.
• W1982783526 hasConcept C2777903533 @default.
• W1982783526 hasConcept C2779689624 @default.
• W1982783526 hasConcept C2780664492 @default.
• W1982783526 hasConcept C42219234 @default.
• W1982783526 hasConcept C541997718 @default.
• W1982783526 hasConcept C55493867 @default.
• W1982783526 hasConcept C71924100 @default.
• W1982783526 hasConcept C98274493 @default.
• W1982783526 hasConceptScore W1982783526C126322002 @default.
• W1982783526 hasConceptScore W1982783526C134018914 @default.
• W1982783526 hasConceptScore W1982783526C178790620 @default.
• W1982783526 hasConceptScore W1982783526C181199279 @default.
• W1982783526 hasConceptScore W1982783526C185592680 @default.
• W1982783526 hasConceptScore W1982783526C25498285 @default.
• W1982783526 hasConceptScore W1982783526C2777903533 @default.
• W1982783526 hasConceptScore W1982783526C2779689624 @default.
• W1982783526 hasConceptScore W1982783526C2780664492 @default.
• W1982783526 hasConceptScore W1982783526C42219234 @default.
• W1982783526 hasConceptScore W1982783526C541997718 @default.
• W1982783526 hasConceptScore W1982783526C55493867 @default.
• W1982783526 hasConceptScore W1982783526C71924100 @default.
• W1982783526 hasConceptScore W1982783526C98274493 @default.
• W1982783526 hasLocation W19827835261 @default.
• W1982783526 hasLocation W19827835262 @default.
• W1982783526 hasLocation W19827835263 @default.
• W1982783526 hasLocation W19827835264 @default.

• next