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- W1982784429 abstract "Teicoplanin is a glycopeptide antibiotic used against established or assumed methicillin-resistant gram-positive infections. An association between teicoplanin treatment and advanced heart block has not been reported to date. A 52-year-old man with end-stage heart failure was admitted for implantation of a left ventricular assist device (Berlin Heart INCOR). Two days after implantation the patient received vancomycin (2 · 1 g/day) and rifampicin (4 · 450 mg/day) because of a central venous catheter infection with coagulase-negative Staphylococci. Thirteen days after LVAD device implantation, the patient developed severe pneumonia. Two days later vancomycin was stopped because of drug-induced leucopenia. Subsequently, vancomycin was then replaced with the glycopeptide teicoplanin at a dose of 600 mg on day 1 and 400 mg QD the following days. The white blood cell count returned to normal in the following days. Five days after begin of teicoplanin therapy orthotopic heart transplantation (HTX) was performed. Immunosuppressive therapy was started with anti-T-lymphocyte-immunglobuline (ATG), cyclosporine, azothioprin and prednisone. Trough plasma levels of teicoplanin were in the range between 13 and 14 mg/l (normal therapeutic range" @default.
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- W1982784429 date "2008-05-12" @default.
- W1982784429 modified "2023-09-26" @default.
- W1982784429 title "Teicoplanin-Induced Complete AV-Block in a Heart Transplant Recipient" @default.
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- W1982784429 doi "https://doi.org/10.1007/s15010-008-7424-5" @default.
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