Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982801310> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1982801310 abstract "Throughout our life cycle, the human body is exposed to harmful microorganisms. The innate immune system is a fundamental factor in the human body, which helpseliminate foreign organisms through specific signalling pathways with the involvement of immune receptors and signalling molecules.Viruses have evolved to infect the host and bypass the host immune responses,however a plethora of Pattern recognition receptors exist in the cell that are capable of detecting viral pathogens and mounting an innate immune response.Herpes simplex Virus Type 2 and Cytomegalovirus are common human pathogens that cause genital ulcerations, organ failure and mental health problems likeencephalitis. In this study, we have aimed to identify the host’s innate immune response to HSV2 and HCMV infection in primary vaginal cells as well as Hela cells.Our data have shown that these viruses are recognized by TLR2 on the cell surface followed by intracellular PRRs such as TLR9, DAI, and IFI16, which trigger cytokineactivation and release. Confocal imaging has revealed that these PRRs are located in different cell compartments and during viral cell entry and replication they canidentify viral presence at specific parts of the cell. Therefore it seems that different PRRs are strategically placed in different cell locations to detect virus invasion and replication in order to activate cytokine secretion and protect the host.When different agonists for PRRs were used it was revealed that they were effective against Herpes virus infection thus indicating that a combination of PRRs agonistsespecially ones that trigger different cytokines could provide a wider spectrum prophylaxis to the host and they can be used to generate efficient treatment againstHSV2 and HCMV infection." @default.
- W1982801310 created "2016-06-24" @default.
- W1982801310 creator A5018732036 @default.
- W1982801310 date "2014-09-24" @default.
- W1982801310 modified "2023-09-23" @default.
- W1982801310 title "Innate immune mechanisms in the recognition ofherpesviridae" @default.
- W1982801310 hasPublicationYear "2014" @default.
- W1982801310 type Work @default.
- W1982801310 sameAs 1982801310 @default.
- W1982801310 citedByCount "0" @default.
- W1982801310 crossrefType "dissertation" @default.
- W1982801310 hasAuthorship W1982801310A5018732036 @default.
- W1982801310 hasConcept C104317684 @default.
- W1982801310 hasConcept C111289621 @default.
- W1982801310 hasConcept C136449434 @default.
- W1982801310 hasConcept C140704245 @default.
- W1982801310 hasConcept C150194340 @default.
- W1982801310 hasConcept C159047783 @default.
- W1982801310 hasConcept C190727270 @default.
- W1982801310 hasConcept C193419808 @default.
- W1982801310 hasConcept C203014093 @default.
- W1982801310 hasConcept C2522874641 @default.
- W1982801310 hasConcept C2779138994 @default.
- W1982801310 hasConcept C2781196997 @default.
- W1982801310 hasConcept C2781236682 @default.
- W1982801310 hasConcept C55493867 @default.
- W1982801310 hasConcept C86803240 @default.
- W1982801310 hasConcept C8891405 @default.
- W1982801310 hasConceptScore W1982801310C104317684 @default.
- W1982801310 hasConceptScore W1982801310C111289621 @default.
- W1982801310 hasConceptScore W1982801310C136449434 @default.
- W1982801310 hasConceptScore W1982801310C140704245 @default.
- W1982801310 hasConceptScore W1982801310C150194340 @default.
- W1982801310 hasConceptScore W1982801310C159047783 @default.
- W1982801310 hasConceptScore W1982801310C190727270 @default.
- W1982801310 hasConceptScore W1982801310C193419808 @default.
- W1982801310 hasConceptScore W1982801310C203014093 @default.
- W1982801310 hasConceptScore W1982801310C2522874641 @default.
- W1982801310 hasConceptScore W1982801310C2779138994 @default.
- W1982801310 hasConceptScore W1982801310C2781196997 @default.
- W1982801310 hasConceptScore W1982801310C2781236682 @default.
- W1982801310 hasConceptScore W1982801310C55493867 @default.
- W1982801310 hasConceptScore W1982801310C86803240 @default.
- W1982801310 hasConceptScore W1982801310C8891405 @default.
- W1982801310 hasLocation W19828013101 @default.
- W1982801310 hasOpenAccess W1982801310 @default.
- W1982801310 hasPrimaryLocation W19828013101 @default.
- W1982801310 hasRelatedWork W1174058088 @default.
- W1982801310 hasRelatedWork W1446958676 @default.
- W1982801310 hasRelatedWork W1975450245 @default.
- W1982801310 hasRelatedWork W1987679698 @default.
- W1982801310 hasRelatedWork W2017161741 @default.
- W1982801310 hasRelatedWork W2022232766 @default.
- W1982801310 hasRelatedWork W2026017133 @default.
- W1982801310 hasRelatedWork W2135143264 @default.
- W1982801310 hasRelatedWork W2145990658 @default.
- W1982801310 hasRelatedWork W2273966940 @default.
- W1982801310 hasRelatedWork W2316550831 @default.
- W1982801310 hasRelatedWork W2431115111 @default.
- W1982801310 hasRelatedWork W2560196942 @default.
- W1982801310 hasRelatedWork W2781794792 @default.
- W1982801310 hasRelatedWork W2891677287 @default.
- W1982801310 hasRelatedWork W2979510703 @default.
- W1982801310 hasRelatedWork W3029570969 @default.
- W1982801310 hasRelatedWork W3093800261 @default.
- W1982801310 hasRelatedWork W3195867609 @default.
- W1982801310 hasRelatedWork W324633592 @default.
- W1982801310 isParatext "false" @default.
- W1982801310 isRetracted "false" @default.
- W1982801310 magId "1982801310" @default.
- W1982801310 workType "dissertation" @default.