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• W1982802248 startingPage "13460" @default.
• W1982802248 abstract "The biological bases of learning and memory are being revealed today with a wide array of molecular approaches, most of which entail the analysis of dysfunction produced by gene disruptions. This perspective derives both from early “genetic dissections” of learning in mutant Drosophila by Seymour Benzer and colleagues and from earlier behavior-genetic analyses of learning and in Diptera by Jerry Hirsch and coworkers. Three quantitative-genetic insights derived from these latter studies serve as guiding principles for the former. First, interacting polygenes underlie complex traits. Consequently, learning/memory defects associated with single-gene mutants can be quantified accurately only in equilibrated, heterogeneous genetic backgrounds. Second, complex behavioral responses will be composed of genetically distinct functional components. Thus, genetic dissection of complex traits into specific biobehavioral properties is likely. Finally, disruptions of genes involved with learning/memory are likely to have pleiotropic effects. As a result, task-relevant sensorimotor responses required for normal learning must be assessed carefully to interpret performance in learning/memory experiments. In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space." @default.
• W1982802248 created "2016-06-24" @default.
• W1982802248 creator A5049326236 @default.
• W1982802248 date "1996-11-26" @default.
• W1982802248 modified "2023-09-26" @default.
• W1982802248 title "Discovery of genes involved with learning and memory: An experimental synthesis of Hirschian and Benzerian perspectives" @default.
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• W1982802248 doi "https://doi.org/10.1073/pnas.93.24.13460" @default.
• W1982802248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/33631" @default.
• W1982802248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8942957" @default.
• W1982802248 hasPublicationYear "1996" @default.
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