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- W1982804789 abstract "SOME years ago, Chassar Moir1 demonstrated by clinical experiments that aqueous extracts of ergot, so far from being valueless as maintained by pharmacologists, contain an oxytocio principle with a remarkably rapid action on the human puerperal uterus. This principle was isolated by Dudley and Moir2 and found to be a water soluble alkaloid, which they named ergometrine. During the process of manufacture of this alkaloid, we have isolated in addition a new alkaloid which is isomeric with ergometrine and convertible into it. The relationship is apparently similar to that existing between the alkaloidal pairs orgotoxine-ergotinine and ergotamine-ergotaminine. We have accordingly named it ergometrinine. In the above-mentioned pairs, one member in each case is comparatively inert. Whether the new alkaloid has the same clinical action as ergometrine or is a relatively inert isomeride remains a question for clinical investigation." @default.
- W1982804789 created "2016-06-24" @default.
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- W1982804789 date "1935-08-01" @default.
- W1982804789 modified "2023-09-25" @default.
- W1982804789 title "A New Alkaloid of Ergot" @default.
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- W1982804789 doi "https://doi.org/10.1038/136259b0" @default.
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