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- W1982804968 abstract "The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with degenerative pathologies, but its role in disease progression is still a matter for debate. Here, we found that mutations in the ER-resident chaperone, neither inactivation nor afterpotential A (NinaA), lead to mild ER stress, protecting photoreceptor neurons from various death stimuli in adult Drosophila. In addition, Drosophila S2 cultured cells, when pre-exposed to mild ER stress, are protected from H(2)O(2), cycloheximide- or ultraviolet-induced cell death. We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death. We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses." @default.
- W1982804968 created "2016-06-24" @default.
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- W1982804968 date "2009-04-02" @default.
- W1982804968 modified "2023-09-27" @default.
- W1982804968 title "ER stress protects from retinal degeneration" @default.
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- W1982804968 doi "https://doi.org/10.1038/emboj.2009.76" @default.
- W1982804968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683051" @default.
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