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• W1982830599 endingPage "8394" @default.
• W1982830599 startingPage "8381" @default.
• W1982830599 abstract "Netrins are guidance cues involved in neural connectivity. We have shown that the netrin-1 receptor DCC (deleted in colorectal cancer) is involved in the functional organization of the mesocorticolimbic dopamine (DA) system. Adult mice with a heterozygous loss-of-function mutation in <i>dcc</i> exhibit changes in indexes of DA function, including DA-related behaviors. These phenotypes are only observed after puberty, a critical period in the maturation of the mesocortical DA projection. Here, we examined whether <i>dcc</i> heterozygous mice exhibit structural changes in medial prefrontal cortex (mPFC) DA synaptic connectivity, before and after puberty. Stereological counts of tyrosine-hydroxylase (TH)-positive varicosities were increased in the cingulate 1 and prelimbic regions of the pregenual mPFC. <i>dcc</i> heterozygous mice also exhibited alterations in the size, complexity, and dendritic spine density of mPFC layer V pyramidal neuron basilar dendritic arbors. Remarkably, these presynaptic and postsynaptic partner phenotypes were not observed in juvenile mice, suggesting that DCC selectively influences the extensive branching and synaptic differentiation that occurs in the maturing mPFC DA circuit at puberty. Immunolabeling experiments in wild-type mice demonstrated that DCC is segregated to TH-positive fibers innervating the nucleus accumbens, with only scarce DCC labeling in mPFC TH-positive fibers. Netrin had an inverted target expression pattern. Thus, DCC-mediated netrin-1 signaling may influence the formation/maintenance of mesocorticolimbic DA topography. In support of this, we report that <i>dcc</i> heterozygous mice exhibit a twofold increase in the density of mPFC DCC/TH-positive varicosities. Our results implicate DCC-mediated netrin-1 signaling in the establishment of mPFC DA circuitry during puberty." @default.
• W1982830599 created "2016-06-24" @default.
• W1982830599 creator A5000657084 @default.
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• W1982830599 date "2011-06-08" @default.
• W1982830599 modified "2023-10-17" @default.
• W1982830599 title "The Netrin Receptor DCC Is Required in the Pubertal Organization of Mesocortical Dopamine Circuitry" @default.
• W1982830599 cites W1522048223 @default.
• W1982830599 cites W1533010316 @default.
• W1982830599 cites W1554434273 @default.
• W1982830599 cites W1605597567 @default.
• W1982830599 cites W1833570973 @default.
• W1982830599 cites W1969523924 @default.
• W1982830599 cites W1970896862 @default.
• W1982830599 cites W1973207691 @default.
• W1982830599 cites W1973371295 @default.
• W1982830599 cites W1978923287 @default.
• W1982830599 cites W1979418246 @default.
• W1982830599 cites W1979719365 @default.
• W1982830599 cites W1981539473 @default.
• W1982830599 cites W1981952273 @default.
• W1982830599 cites W1985142350 @default.
• W1982830599 cites W1985645068 @default.
• W1982830599 cites W1986336068 @default.
• W1982830599 cites W1988196067 @default.
• W1982830599 cites W1990996190 @default.
• W1982830599 cites W1992111877 @default.
• W1982830599 cites W1992595542 @default.
• W1982830599 cites W1993826962 @default.
• W1982830599 cites W1994705524 @default.
• W1982830599 cites W1995816684 @default.
• W1982830599 cites W2005054269 @default.
• W1982830599 cites W2007760226 @default.
• W1982830599 cites W2008631499 @default.
• W1982830599 cites W2015247295 @default.
• W1982830599 cites W2018883639 @default.
• W1982830599 cites W2021796006 @default.
• W1982830599 cites W2024168811 @default.
• W1982830599 cites W2026010744 @default.
• W1982830599 cites W2028496416 @default.
• W1982830599 cites W2030055333 @default.
• W1982830599 cites W2032435549 @default.
• W1982830599 cites W2037980186 @default.
• W1982830599 cites W2039119365 @default.
• W1982830599 cites W2045539365 @default.
• W1982830599 cites W2046969288 @default.
• W1982830599 cites W2048064435 @default.
• W1982830599 cites W2048508937 @default.
• W1982830599 cites W2052086914 @default.
• W1982830599 cites W2060015752 @default.
• W1982830599 cites W2060649852 @default.
• W1982830599 cites W2061196115 @default.
• W1982830599 cites W2061407859 @default.
• W1982830599 cites W2063365688 @default.
• W1982830599 cites W2064591722 @default.
• W1982830599 cites W2066035443 @default.
• W1982830599 cites W2068406343 @default.
• W1982830599 cites W2069582700 @default.
• W1982830599 cites W2069621692 @default.
• W1982830599 cites W2071656982 @default.
• W1982830599 cites W2085644733 @default.
• W1982830599 cites W2086151698 @default.
• W1982830599 cites W2087129491 @default.
• W1982830599 cites W2089202196 @default.
• W1982830599 cites W2089312971 @default.
• W1982830599 cites W2089904804 @default.
• W1982830599 cites W2090006102 @default.
• W1982830599 cites W2091574145 @default.
• W1982830599 cites W2098205950 @default.
• W1982830599 cites W2098529644 @default.
• W1982830599 cites W2101671662 @default.
• W1982830599 cites W2101732484 @default.
• W1982830599 cites W2104175189 @default.
• W1982830599 cites W2110277932 @default.
• W1982830599 cites W2111405228 @default.
• W1982830599 cites W2116900663 @default.
• W1982830599 cites W2125802379 @default.
• W1982830599 cites W2127500210 @default.
• W1982830599 cites W2128646985 @default.
• W1982830599 cites W2130259686 @default.
• W1982830599 cites W2131477570 @default.
• W1982830599 cites W2134624334 @default.
• W1982830599 cites W2137587432 @default.
• W1982830599 cites W2143080892 @default.
• W1982830599 cites W2146936296 @default.
• W1982830599 cites W2150503009 @default.
• W1982830599 cites W2156213901 @default.
• W1982830599 cites W2162482297 @default.
• W1982830599 cites W2163408424 @default.
• W1982830599 cites W2169725112 @default.
• W1982830599 cites W2312823188 @default.
• W1982830599 cites W2409579970 @default.

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