FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982833897> ?p ?o ?g. }

• W1982833897 endingPage "19552" @default.
• W1982833897 startingPage "19552" @default.
• W1982833897 abstract "Introduction Due to its side effects stavudine (D4T) has been replaced by zidovudine (AZT) and tenofovir (TDF) in most low- and middle-income countries (LMICs). In 2014 about 38% of adult first-line regimens contain AZT and 62% TDF [1]. Whereas the unfavourable metabolic outcomes of D4T in comparison to TDF have been described extensively, studies from LMICs comparing metabolic profiles between patients on AZT and TDF are scarce. Given the high number of patients in LMICs still taking AZT, data on their metabolic profile are needed. We present rates of metabolic syndrome (MS) in adult patients taking either AZT- or TDF-containing first-line, non-nucleoside reverse transcriptase (NNRTI)-based regimens. Materials and Methods Data derived from a cross-sectional multi-disease screening conducted in ten facilities in two rural districts of Lesotho, Southern Africa [2]. Patients were eligible if aged ≥25 years and on NNRTI-containing first-line ART ≥6 months. The MS definition for Africa of the International Diabetes Federation was applied [3]. Assessed potential predictors for MS were age, time on ART, virologic suppression, body-mass index (BMI), alcohol consumption, wealth quintile, NNRTI (nevirapine (NVP) or Efavirenz (EFV)), history of previous D4T exposure and ART-backbone (AZT or TDF). Statistical analyses – stratified for sex – comprised univariate logistic regression for each predictor variable with subsequent construction of a multivariate model including all predictors with an association to MS at a significance level<0.1 in univariate analysis. Results Out of 1026 patients, 660 (64.3%) were female. MS prevalence was 9.8% (95% CI 6.9–13.4) in men and 22.9% (19.7–26.3) in women. In women, aged ≥35 years, AZT-backbone, NVP-base, BMI ≥25kg/m2 and taking ART for ≥4.5 years were associated with MS in univariate analysis. In the multivariate model only AZT (adjusted odds-ratio: 2.2, 95% CI 1.4–3.6; p=0.001) and BMI ≥25kg/m2 (9.8; 2.8–34.1, p<0.001) were associated with MS. For men, age, higher wealth quintile, history of D4T exposure and BMI were associated with MS in univariate analysis. In the multivariate model only a BMI ≥25kg/m2 was associated with MS (8.9; 3.8–20.9, p<0.001). Conclusions In rural Lesotho, Southern Africa, the use of AZT instead of TDF among women who are on ART for ≥6 months predisposes to the development of metabolic syndrome. Given that, still 38% of first-line regimens in LMIC contain AZT, this finding needs to be verified in other settings in Sub-Saharan Africa." @default.
• W1982833897 created "2016-06-24" @default.
• W1982833897 creator A5004560776 @default.
• W1982833897 creator A5011049589 @default.
• W1982833897 creator A5012249009 @default.
• W1982833897 creator A5024961182 @default.
• W1982833897 creator A5028128458 @default.
• W1982833897 creator A5031304623 @default.
• W1982833897 creator A5050750945 @default.
• W1982833897 creator A5058695007 @default.
• W1982833897 creator A5064575230 @default.
• W1982833897 creator A5069357044 @default.
• W1982833897 creator A5079419922 @default.
• W1982833897 date "2014-11-01" @default.
• W1982833897 modified "2023-10-01" @default.
• W1982833897 title "Higher rates of metabolic syndrome among women taking zidovudine as compared to tenofovir in rural Africa: preliminary data from the CART-1 study" @default.
• W1982833897 cites W2120336033 @default.
• W1982833897 doi "https://doi.org/10.7448/ias.17.4.19552" @default.
• W1982833897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224833" @default.
• W1982833897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25394059" @default.
• W1982833897 hasPublicationYear "2014" @default.
• W1982833897 type Work @default.
• W1982833897 sameAs 1982833897 @default.
• W1982833897 citedByCount "4" @default.
• W1982833897 countsByYear W19828338972016 @default.
• W1982833897 countsByYear W19828338972017 @default.
• W1982833897 crossrefType "journal-article" @default.
• W1982833897 hasAuthorship W1982833897A5004560776 @default.
• W1982833897 hasAuthorship W1982833897A5011049589 @default.
• W1982833897 hasAuthorship W1982833897A5012249009 @default.
• W1982833897 hasAuthorship W1982833897A5024961182 @default.
• W1982833897 hasAuthorship W1982833897A5028128458 @default.
• W1982833897 hasAuthorship W1982833897A5031304623 @default.
• W1982833897 hasAuthorship W1982833897A5050750945 @default.
• W1982833897 hasAuthorship W1982833897A5058695007 @default.
• W1982833897 hasAuthorship W1982833897A5064575230 @default.
• W1982833897 hasAuthorship W1982833897A5069357044 @default.
• W1982833897 hasAuthorship W1982833897A5079419922 @default.
• W1982833897 hasBestOaLocation W19828338971 @default.
• W1982833897 hasConcept C126322002 @default.
• W1982833897 hasConcept C142462285 @default.
• W1982833897 hasConcept C144301174 @default.
• W1982833897 hasConcept C151956035 @default.
• W1982833897 hasConcept C159047783 @default.
• W1982833897 hasConcept C2777351918 @default.
• W1982833897 hasConcept C2779130552 @default.
• W1982833897 hasConcept C2779889181 @default.
• W1982833897 hasConcept C2780216070 @default.
• W1982833897 hasConcept C2780221984 @default.
• W1982833897 hasConcept C2780578515 @default.
• W1982833897 hasConcept C2780727368 @default.
• W1982833897 hasConcept C2781432083 @default.
• W1982833897 hasConcept C2993143319 @default.
• W1982833897 hasConcept C3013748606 @default.
• W1982833897 hasConcept C38180746 @default.
• W1982833897 hasConcept C511355011 @default.
• W1982833897 hasConcept C71924100 @default.
• W1982833897 hasConcept C99454951 @default.
• W1982833897 hasConceptScore W1982833897C126322002 @default.
• W1982833897 hasConceptScore W1982833897C142462285 @default.
• W1982833897 hasConceptScore W1982833897C144301174 @default.
• W1982833897 hasConceptScore W1982833897C151956035 @default.
• W1982833897 hasConceptScore W1982833897C159047783 @default.
• W1982833897 hasConceptScore W1982833897C2777351918 @default.
• W1982833897 hasConceptScore W1982833897C2779130552 @default.
• W1982833897 hasConceptScore W1982833897C2779889181 @default.
• W1982833897 hasConceptScore W1982833897C2780216070 @default.
• W1982833897 hasConceptScore W1982833897C2780221984 @default.
• W1982833897 hasConceptScore W1982833897C2780578515 @default.
• W1982833897 hasConceptScore W1982833897C2780727368 @default.
• W1982833897 hasConceptScore W1982833897C2781432083 @default.
• W1982833897 hasConceptScore W1982833897C2993143319 @default.
• W1982833897 hasConceptScore W1982833897C3013748606 @default.
• W1982833897 hasConceptScore W1982833897C38180746 @default.
• W1982833897 hasConceptScore W1982833897C511355011 @default.
• W1982833897 hasConceptScore W1982833897C71924100 @default.
• W1982833897 hasConceptScore W1982833897C99454951 @default.
• W1982833897 hasLocation W19828338971 @default.
• W1982833897 hasLocation W19828338972 @default.
• W1982833897 hasLocation W19828338973 @default.
• W1982833897 hasLocation W19828338974 @default.
• W1982833897 hasLocation W19828338975 @default.
• W1982833897 hasLocation W19828338976 @default.
• W1982833897 hasOpenAccess W1982833897 @default.
• W1982833897 hasPrimaryLocation W19828338971 @default.
• W1982833897 hasRelatedWork W1489059043 @default.
• W1982833897 hasRelatedWork W1512346648 @default.
• W1982833897 hasRelatedWork W1965681484 @default.
• W1982833897 hasRelatedWork W1980072598 @default.
• W1982833897 hasRelatedWork W1995798071 @default.
• W1982833897 hasRelatedWork W2004149229 @default.
• W1982833897 hasRelatedWork W2012874061 @default.
• W1982833897 hasRelatedWork W2023433096 @default.
• W1982833897 hasRelatedWork W2031091719 @default.
• W1982833897 hasRelatedWork W2076663478 @default.
• W1982833897 hasRelatedWork W2094859659 @default.
• W1982833897 hasRelatedWork W2104079629 @default.
• W1982833897 hasRelatedWork W2104725842 @default.

• next