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- W1982854599 abstract "Fibrinogen-related proteins (FREPs) are hypothesized to function in non-self-recognition in the snail Biomphalaria glabrata. To investigate this assumption, the expression of four members of the FREP gene family was studied using quantitative PCR at 0.5–16 days following exposure of M line and BS-90 strain B. glabrata to Echinostoma paraensei and Schistosoma mansoni. Both strains react to, but fail to eliminate E. paraensei. Only the BS-90 strain is immunologically resistant to S. mansoni. Both snail strains responded to E. paraensei with significantly elevated expression of FREP 2 and 4. Following exposure to S. mansoni, resistant BS-90 snails showed an increase in expression of FREP 2 and 4 (57-fold and 4.5-fold increase, respectively), susceptible M line snails did not display a FREP response. Expression of FREP 3 and 7 was not significantly elevated in any snail/trematode combination. These expression profiles support the hypothesis that some FREPs play a role in the anti-trematode responses in B. glabrata." @default.
- W1982854599 created "2016-06-24" @default.
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- W1982854599 date "2005-01-01" @default.
- W1982854599 modified "2023-09-26" @default.
- W1982854599 title "Differential expression of FREP genes in two strains of Biomphalaria glabrata following exposure to the digenetic trematodes Schistosoma mansoni and Echinostoma paraensei" @default.
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- W1982854599 doi "https://doi.org/10.1016/j.dci.2004.08.003" @default.
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