Matches in SemOpenAlex for { <https://semopenalex.org/work/W198285944> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W198285944 abstract "Summary Since cannabinoids inhibit the uptake of biogenic amines into synaptosomes in vitro, the effects of chronic and acute (—)Δ1-tetrahydrocannabinol [(—)Δ1-THC] administration on the uptake of 3H-dopamine (3H-DA) into cortical and striatal synaptosomes from mouse brain were tested in the present study. To test whether the effects of (—)Δ1-THC on 3H-DA uptake are specific, (—)Δ1-THC was compared to (+)Δ6-THC administration. The uptake of 3H-DA into cortical synaptosomes increased in mice pretreated acutely with (—)Δ1-THC or cannabidiol (CBD) but not in mice pretreated with (+)Δ6-THC. The 3H-DA uptake was no longer increased after chronic (1 week) treatment with (—)Δ1-THC. The effect of in vivo treatment with (—)Δ1-THC on the in vitro uptake was not specific to 3H-DA, but enhanced also the uptake of 3H-norepinephrine (3H-NE), 3H-5-hydroxytryptamine (3H-5HT), and 3H-γ-aminobutyric acid (3H-GABA) into cortical or whole brain synaptosomes. Intravenous administration of dopamine or norepinephrine receptor antagonists, i.e. chlorpromazine, haloperidol or propanolol, enhanced the uptake of 3H-DA, and 3H-NE respectively into cortical synaptosomes. Pretreatment with uptake inhibitors such as the tricyclic antidepressants, amphetamine, or with the monoamine oxidase inhibitor, pargyline, caused an inhibition of the uptake of 3H-DA or 3H-NE into the isolated synaptosomes. It is suggested that in vivo (—)Δ1-THC does not act on uptake mechanism but on receptors." @default.
- W198285944 created "2016-06-24" @default.
- W198285944 creator A5012022294 @default.
- W198285944 date "1979-01-01" @default.
- W198285944 modified "2023-09-23" @default.
- W198285944 title "THE EFFECT OF IN VIVO TREATMENT WITH (—)Δ1-TETRAHYDROCANNABINOL, AND OTHER PSYCHOACTIVE DRUGS ON THE IN VITRO UPTAKE OF BIOGENIC AMINES" @default.
- W198285944 cites W1853288408 @default.
- W198285944 cites W1931517214 @default.
- W198285944 cites W1971926900 @default.
- W198285944 cites W1973618134 @default.
- W198285944 cites W1974310960 @default.
- W198285944 cites W1986995831 @default.
- W198285944 cites W1987225271 @default.
- W198285944 cites W1988629864 @default.
- W198285944 cites W2003692600 @default.
- W198285944 cites W2006513423 @default.
- W198285944 cites W2043866686 @default.
- W198285944 cites W2085996570 @default.
- W198285944 cites W2094009841 @default.
- W198285944 cites W2139214499 @default.
- W198285944 cites W2176174715 @default.
- W198285944 cites W2284589253 @default.
- W198285944 cites W2598020173 @default.
- W198285944 cites W3208810861 @default.
- W198285944 cites W79312590 @default.
- W198285944 doi "https://doi.org/10.1016/b978-0-08-023759-6.50030-5" @default.
- W198285944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/756835" @default.
- W198285944 hasPublicationYear "1979" @default.
- W198285944 type Work @default.
- W198285944 sameAs 198285944 @default.
- W198285944 citedByCount "2" @default.
- W198285944 crossrefType "book-chapter" @default.
- W198285944 hasAuthorship W198285944A5012022294 @default.
- W198285944 hasConcept C118552586 @default.
- W198285944 hasConcept C134018914 @default.
- W198285944 hasConcept C150903083 @default.
- W198285944 hasConcept C170493617 @default.
- W198285944 hasConcept C181199279 @default.
- W198285944 hasConcept C185592680 @default.
- W198285944 hasConcept C187714386 @default.
- W198285944 hasConcept C207001950 @default.
- W198285944 hasConcept C2775864247 @default.
- W198285944 hasConcept C2776024655 @default.
- W198285944 hasConcept C2776284327 @default.
- W198285944 hasConcept C2776895053 @default.
- W198285944 hasConcept C2777056318 @default.
- W198285944 hasConcept C2777067607 @default.
- W198285944 hasConcept C2778514916 @default.
- W198285944 hasConcept C2778563155 @default.
- W198285944 hasConcept C2778775820 @default.
- W198285944 hasConcept C2780871563 @default.
- W198285944 hasConcept C2780948584 @default.
- W198285944 hasConcept C513476851 @default.
- W198285944 hasConcept C55493867 @default.
- W198285944 hasConcept C71924100 @default.
- W198285944 hasConcept C86803240 @default.
- W198285944 hasConcept C98274493 @default.
- W198285944 hasConceptScore W198285944C118552586 @default.
- W198285944 hasConceptScore W198285944C134018914 @default.
- W198285944 hasConceptScore W198285944C150903083 @default.
- W198285944 hasConceptScore W198285944C170493617 @default.
- W198285944 hasConceptScore W198285944C181199279 @default.
- W198285944 hasConceptScore W198285944C185592680 @default.
- W198285944 hasConceptScore W198285944C187714386 @default.
- W198285944 hasConceptScore W198285944C207001950 @default.
- W198285944 hasConceptScore W198285944C2775864247 @default.
- W198285944 hasConceptScore W198285944C2776024655 @default.
- W198285944 hasConceptScore W198285944C2776284327 @default.
- W198285944 hasConceptScore W198285944C2776895053 @default.
- W198285944 hasConceptScore W198285944C2777056318 @default.
- W198285944 hasConceptScore W198285944C2777067607 @default.
- W198285944 hasConceptScore W198285944C2778514916 @default.
- W198285944 hasConceptScore W198285944C2778563155 @default.
- W198285944 hasConceptScore W198285944C2778775820 @default.
- W198285944 hasConceptScore W198285944C2780871563 @default.
- W198285944 hasConceptScore W198285944C2780948584 @default.
- W198285944 hasConceptScore W198285944C513476851 @default.
- W198285944 hasConceptScore W198285944C55493867 @default.
- W198285944 hasConceptScore W198285944C71924100 @default.
- W198285944 hasConceptScore W198285944C86803240 @default.
- W198285944 hasConceptScore W198285944C98274493 @default.
- W198285944 hasLocation W1982859441 @default.
- W198285944 hasLocation W1982859442 @default.
- W198285944 hasOpenAccess W198285944 @default.
- W198285944 hasPrimaryLocation W1982859441 @default.
- W198285944 hasRelatedWork W130215191 @default.
- W198285944 hasRelatedWork W1943820892 @default.
- W198285944 hasRelatedWork W1970923864 @default.
- W198285944 hasRelatedWork W1982596974 @default.
- W198285944 hasRelatedWork W1984378659 @default.
- W198285944 hasRelatedWork W1991972140 @default.
- W198285944 hasRelatedWork W2077284622 @default.
- W198285944 hasRelatedWork W2332785275 @default.
- W198285944 hasRelatedWork W2464608421 @default.
- W198285944 hasRelatedWork W3198119351 @default.
- W198285944 isParatext "false" @default.
- W198285944 isRetracted "false" @default.
- W198285944 magId "198285944" @default.
- W198285944 workType "book-chapter" @default.