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• W1982860588 abstract "The concept that the ligand-binding domain of vertebrate glutamate receptor channels and bacterial periplasmic substrate-binding proteins (PBPs) share similar three-dimensional (3D) structures has gained increasing support in recent years. On the basis of a dual approach that included computer-assisted molecular modelling and functional studies of site-specific mutants, theoretical 3D models of this domain have been proposed. This article reviews to what extent these models could predict the crystal structure of the ligand-binding domain of an ionotropic glutamate receptor subunit recently determined at high resolution by X-ray diffraction studies." @default.
• W1982860588 created "2016-06-24" @default.
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• W1982860588 date "2000-03-01" @default.
• W1982860588 modified "2023-09-24" @default.
• W1982860588 title "How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors" @default.
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• W1982860588 doi "https://doi.org/10.1016/s0165-6147(99)01443-1" @default.
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