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- W1982861337 abstract "Effects of embryonic exposure to aflatoxin-B1 (AFB1) on the postnatal development of chicken mononuclear phagocytic system function was examined. Single exposure of 6-d chick embryos to 0.1, 0.5, and 1 μg AFB1 in 10 μL acetone was employed. Control embryos received 10 μl solvent and sham-treated controls included embryos with a hole in the egg shell with no compound added. Aflatoxin B1 exposure caused a dose-related increase in embryonic mortality. After hatch, no differences were observed in body weight gain among treatment groups. The incidence of circulating thrombocytes was reduced in chicks exposed to the highest AFB1 dose with enhancement in monocyte and lymphocyte cell populations. Birds exposed to 1 μg AFB1 recruited fewer macrophages in the peritoneal cavity after i.p. Sephadex elicitation along with reduced substrate adherence potential of peritoneal exudate cells. Similarly, macrophages from 0.5 and 1 μg AFB1-treated birds had depressed phagocytic potential. These results suggest that long-term immune depression of macrophage-mediated functions can occur following embryonic exposure to AFB1." @default.
- W1982861337 created "2016-06-24" @default.
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- W1982861337 date "1992-03-01" @default.
- W1982861337 modified "2023-09-27" @default.
- W1982861337 title "Effects of AFB1 embryonic exposure on chicken mononuclear phagocytic cell functions" @default.
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- W1982861337 doi "https://doi.org/10.1016/0145-305x(92)90018-8" @default.
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