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- W1982870968 abstract "The presence of an alkamide in lichens is reported for the first time. The alkamide was isolated from Stereocaulon alpinum Laur. and identified through spectroscopic analysis as 9-cis-octa-decenamide (1). With reference to previously known activity of alkamides from both the plant and animal kingdoms on inflammatory processes, 1 was tested for in vitro inhibitory activity against the key enzymes of the major pathways involved in arachidonate metabolism. The compound was shown to exhibit moderate dose-dependent inhibitory activity against cyclooxygenase from sheep seminal vesicle microsomes (IC(50) = 64.3 μM) whilst showing only slight activity against 5-lipoxygenase from porcine leucocytes." @default.
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- W1982870968 date "1997-12-01" @default.
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- W1982870968 title "Biologically active alkamide from the lichen Stereocaulon alpinum" @default.
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- W1982870968 doi "https://doi.org/10.1016/s0944-7113(97)80042-6" @default.
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