Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982884872> ?p ?o ?g. }
- W1982884872 abstract "In Saccharomyces cerevisiae, PRS genes comprise a family of five paralogous genes. Previously, it has been shown that in the cell the gene products are organized into two interacting complexes, one of which is a heterodimer and the other a heterotrimer. Here, it has been demonstrated that in addition to supplying the cell with the key metabolic intermediate PRPP [5-phospho-D-ribosyl-1(alpha)-pyrophosphate], the gene products contribute to the maintenance of cell integrity. Specifically, the phosphorylation of Rlm1, one of the end points of the cell integrity signalling pathway, is significantly impaired following deletion of any one of the PRS genes, in particular PRS1 and PRS3. This is reflected in changes in the expression of the alternative 1,3-beta-glucan synthase catalytic subunit, Fks2, as measured by its promoter activity. Yeast two-hybrid analysis has shown that Prs1, specifically the non-homologous region, NHR1-1 and Prs3, and to a lesser extent Prs2 and Prs4, interact with the MAPK (mitogen-activated protein kinase) of the cell integrity pathway, Slt2. When PRS1 is lacking, the basal level of phosphorylation of Slt2 is increased. Furthermore, prs1Delta and prs3Delta strains have an increased chitin content under normal growth conditions. alpha-Factor sensitivity and Calcofluor White resistance associated with the lack of Prs1 and Prs3 corroborate the involvement of these two gene products in cell integrity signalling. It is postulated that Prs polypeptides play a significant role in the remodelling of the cell wall and may have a direct involvement in cell integrity signalling." @default.
- W1982884872 created "2016-06-24" @default.
- W1982884872 creator A5018242203 @default.
- W1982884872 creator A5037033352 @default.
- W1982884872 creator A5051791009 @default.
- W1982884872 creator A5090282550 @default.
- W1982884872 date "2004-10-01" @default.
- W1982884872 modified "2023-09-24" @default.
- W1982884872 title "Impaired PRPP-synthesizing capacity compromises cell integrity signalling in Saccharomyces cerevisiae" @default.
- W1982884872 cites W1484575698 @default.
- W1982884872 cites W1485925377 @default.
- W1982884872 cites W1514092148 @default.
- W1982884872 cites W1526043578 @default.
- W1982884872 cites W1546783991 @default.
- W1982884872 cites W1553096032 @default.
- W1982884872 cites W1566478858 @default.
- W1982884872 cites W1581281722 @default.
- W1982884872 cites W1781742152 @default.
- W1982884872 cites W181622860 @default.
- W1982884872 cites W1857242751 @default.
- W1982884872 cites W1903792504 @default.
- W1982884872 cites W1906221324 @default.
- W1982884872 cites W1938343654 @default.
- W1982884872 cites W1965106998 @default.
- W1982884872 cites W1967390330 @default.
- W1982884872 cites W1968595539 @default.
- W1982884872 cites W1971222979 @default.
- W1982884872 cites W1973513869 @default.
- W1982884872 cites W1975035065 @default.
- W1982884872 cites W1979342595 @default.
- W1982884872 cites W1990755713 @default.
- W1982884872 cites W1993096123 @default.
- W1982884872 cites W1997335986 @default.
- W1982884872 cites W2002960804 @default.
- W1982884872 cites W2017619665 @default.
- W1982884872 cites W2021129192 @default.
- W1982884872 cites W2022043674 @default.
- W1982884872 cites W2027535635 @default.
- W1982884872 cites W2032018179 @default.
- W1982884872 cites W2040518083 @default.
- W1982884872 cites W2040838736 @default.
- W1982884872 cites W2041847099 @default.
- W1982884872 cites W2043101069 @default.
- W1982884872 cites W2043811875 @default.
- W1982884872 cites W2051440750 @default.
- W1982884872 cites W2055805834 @default.
- W1982884872 cites W2064059521 @default.
- W1982884872 cites W2065220166 @default.
- W1982884872 cites W2065304353 @default.
- W1982884872 cites W2077141078 @default.
- W1982884872 cites W2079122560 @default.
- W1982884872 cites W2086660631 @default.
- W1982884872 cites W2087410635 @default.
- W1982884872 cites W2089846702 @default.
- W1982884872 cites W2105634866 @default.
- W1982884872 cites W2106031809 @default.
- W1982884872 cites W2109913844 @default.
- W1982884872 cites W2123280311 @default.
- W1982884872 cites W2126334121 @default.
- W1982884872 cites W2128635872 @default.
- W1982884872 cites W2129770809 @default.
- W1982884872 cites W2136623592 @default.
- W1982884872 cites W2137056661 @default.
- W1982884872 cites W2142161768 @default.
- W1982884872 cites W2143924086 @default.
- W1982884872 cites W2147186623 @default.
- W1982884872 cites W2149239345 @default.
- W1982884872 cites W2152568223 @default.
- W1982884872 cites W2157460441 @default.
- W1982884872 cites W2159100436 @default.
- W1982884872 cites W2161906145 @default.
- W1982884872 cites W2162102216 @default.
- W1982884872 cites W2166322587 @default.
- W1982884872 cites W2167869241 @default.
- W1982884872 cites W2346508339 @default.
- W1982884872 cites W2411665017 @default.
- W1982884872 cites W34908489 @default.
- W1982884872 cites W70864286 @default.
- W1982884872 cites W93651929 @default.
- W1982884872 doi "https://doi.org/10.1099/mic.0.27373-0" @default.
- W1982884872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15470112" @default.
- W1982884872 hasPublicationYear "2004" @default.
- W1982884872 type Work @default.
- W1982884872 sameAs 1982884872 @default.
- W1982884872 citedByCount "21" @default.
- W1982884872 countsByYear W19828848722013 @default.
- W1982884872 countsByYear W19828848722015 @default.
- W1982884872 countsByYear W19828848722016 @default.
- W1982884872 countsByYear W19828848722017 @default.
- W1982884872 countsByYear W19828848722018 @default.
- W1982884872 countsByYear W19828848722019 @default.
- W1982884872 countsByYear W19828848722020 @default.
- W1982884872 countsByYear W19828848722022 @default.
- W1982884872 crossrefType "journal-article" @default.
- W1982884872 hasAuthorship W1982884872A5018242203 @default.
- W1982884872 hasAuthorship W1982884872A5037033352 @default.
- W1982884872 hasAuthorship W1982884872A5051791009 @default.
- W1982884872 hasAuthorship W1982884872A5090282550 @default.
- W1982884872 hasBestOaLocation W19828848721 @default.
- W1982884872 hasConcept C104292427 @default.