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- W1982885280 abstract "The Dictionary of Gene Technology (2nd edition)by Gunter Kahl. Wiley-VCH, 2001. $155 hardcover (958 pages)ISBN: 3-527-30100-3Are you frequently confused by terms such as ‘multiplex walking’, ‘multiplex sequencing’, and ‘multiplex PCR’? Do you at times feel lost facing phrases such as ‘gene conversion’ or ‘nonsense supression’ in new research papers? Would you admit that you are not quite sure what the difference between pharmacogenetics and pharmocogenomics is all about? Or for that matter, what the abbreviations Q-PCR and QRT-PCR stand for? If the answer to one or more of the above is positive then very likely you will benefit from a personal copy of The Dictionary of Gene Technology. This book is much more that what its concise title implies – it is more than merely a dictionary, in the sense of a collection of terms and acronyms, but rather a self-sufficient research tool, an illuminating read, and in fact an entire encyclopedia for the post-genomic era.Gunter Kahl has accomplished what might at first sight seem to be an almost unrealistic task – creating a comprehensive, accurate, useful, intelligent and readable account of virtually every possible term from the many diverse fields of genomic research. Moreover, this colossal task has been accomplished with an unequivocal and consistent language, so that even newcomers to genomic research will not feel being left out. Virtually every graduate of basic biology will be able to catch up on the complex terms, comprising in fact a whole new technical dialect, that evolved in the late 1980s and the 1990s along with the explosion in techniques, biological insight and massive flow of data that followed the invention of PCR. This is evident from the addition of over 2500 new entries (now making a total of over 6500 entries) since the first edition of this book was published in 1994 – on average about ten new terms added each week since!Notably, the indexed terms also include numerous plainly explained traditional biochemical entries, so that even the lay reader can successfully navigate the more complex ‘new genomics’ lingo. The more recent, genomic-style definitions are at times abundant in cross-referenced terms, which may at first seem bothersome, yet is inescapable when cataloging an almost entirely new technical language. For example, a typical definition reads as follows:‘Expressed sequence tag polymorphism (ESTP): Any difference in → DNA sequence between two (or more) → expressed sequence tags (ESTs), that can be detected by either → restriction digestion of the ESTs, or by separation of polymorphic sequences using → denaturing gradient electrophoresis. EPSPs can be used to screen for DNA → polymorphisms in populations, or serve as → markers in → mapping and → comparative mapping procedures.’Confused? Well, this is a relatively simple definition – more elaborate ones are abundant in the text. Definitely, using English (or any other human language, for that matter) for defining genomic technologies takes it to its limits. Yet, trying to use other methods for definitions would have made this book extremely hefty. It is a small miracle that such a huge magnitude of terms and definitions is contained in merely 907 pages of the main A–Z text. Moreover, once you get used to the ‘arrowhead’ style, you slowly realize that you are becoming an expert in gene technology as you read along the text.A major advantage of the book is the abundance of clearly outlined chemical structures, biochemical reaction schemes, helpful line illustrations and practical assay diagrams. The book also includes a very useful appendix, containing lists of DNA restriction enzymes, genomic research web resources, and genome-oriented scientific journals (though without their respective electronic edition web sites). Yet, a glossary of the most fundamental terms, as well as a short introduction to gene technology, would have been a welcomed addition for newcomers to genomics, so that they will be able to walk through the text more easily without stumbling on too many arrowheads along the way.A few words of criticism are due, though. It is a pity that at $155, this book is priced somewhat beyond the typical range for biology textbooks. At this price, you would at least expect to receive a companion CD-ROM – having access to this text through the PC desktop would have been extremely useful when overwhelmed with scientific manuscripts. Given the fact that this book could serve as an indispensable companion for undergraduate, graduate and postgraduate students, one might hope that a soft-cover, more reasonably priced edition will soon follow. But if you can afford the price, my advice is to get a copy before the book runs out of print: it will be a valuable companion for many years. A hard cover edition, after all, is the best guarantee that such a practical book will not become crumpled from being consulted time and again – and it will." @default.
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- W1982885280 date "2002-04-01" @default.
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- W1982885280 title "The Dictionary of Gene Technology (2nd edition): A landmark research tool for the post-genomic era" @default.
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