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• W1982893757 abstract "The mechanisms underlying antiepileptic or antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS) are poorly understood. In this study, we investigated the effect of rTMS applied during rapid amygdala kindling on some electrophysiological properties of hippocampal CA1 pyramidal neurons. Male Wistar rats were kindled by daily electrical stimulation of the basolateral amygdala in a semi-rapid manner (12 stimulations/day) until they achieved stage-5 seizure. One group (kindled + rTMS (KrTMS)) of animals received rTMS (1 Hz for 4 min) 5 min after termination of daily kindling stimulations. Twenty four hours following the last kindling stimulation electrophysiological properties of hippocampal CA1 pyramidal neurons were investigated using whole-cell patch-clamp technique. Amygdala kindling significantly depolarized the resting membrane potential and increased the input resistance, spontaneous firing activity, number of evoked spikes and half-width of the first evoked spike. Kindling also decreased the first-spike latency and amplitude significantly. Application of rTMS during kindling somehow prevented the development of seizures and protected CA1 pyramidal neurons of hippocampus against deleterious effect of kindling on both passive and active neuronal electrophysiological properties. Interestingly, application of rTMS alone enhanced the excitability of CA1 pyramidal neurons significantly. Based on the results of our study, it may be suggested that rTMS exerts its anticonvulsant effect, in part, through preventing the amygdala kindling-induced changes in electrophysiological properties of hippocampal CA1 pyramidal neurons. It seems that rTMS exerts protective effects on the neural circuits involved in spreading the seizures from the focus to other parts of the brain." @default.
• W1982893757 created "2016-06-24" @default.
• W1982893757 creator A5001454608 @default.
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• W1982893757 creator A5052614477 @default.
• W1982893757 creator A5076245313 @default.
• W1982893757 creator A5066412071 @default.
• W1982893757 date "2014-11-01" @default.
• W1982893757 modified "2023-10-10" @default.
• W1982893757 title "Repeated transcranial magnetic stimulation prevents kindling-induced changes in electrophysiological properties of rat hippocampal CA1 pyramidal neurons" @default.
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• W1982893757 doi "https://doi.org/10.1016/j.neuroscience.2014.09.022" @default.
• W1982893757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25241070" @default.
• W1982893757 hasPublicationYear "2014" @default.
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