FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982910460> ?p ?o ?g. }

• W1982910460 endingPage "424" @default.
• W1982910460 startingPage "411" @default.
• W1982910460 abstract "Aging represents a major risk factor for the development and progression of Parkinson disease (PD), a chronic degenerative disorder characterized by the selective loss of dopaminergic (DAergic) neurons in the subtantia nigra pars compacta (SNpc). Emerging evidence highlights the glia as a pivotal factor in PD etiology, and epidemiological studies indicate that certain nonsteroidal antiinflammatory drugs (NSAIDs) may prevent or delay the progression of PD. Given that the exaggerated inflammatory response observed in old age may play a critical role in exacerbating DAergic vulnerability, we hypothesize here that switching the harmful glial response to inflammation and oxidative stress might increase the ability of the SN to resist inflammatory attacks. To this end, we developed a treatment in which we combined the effects of nitric oxide (NO) with nonsteroidal antiinflammatory activity by using HCT1026, a NO-donating derivative of flurbiprofen that has a safe profile and additional immunomodulatory properties. Young and aged mice fed with control or HCT1026 (30 mg kg(-1) day(-1)) diet were exposed to a single systemic injection of a subtoxic dose (0.2 mg kg(-1)) of lipopolysaccharide (LPS), one of the most extensively used glial activators. HCT1026 efficiently reversed the age-dependent increase of microglial activation in response to LPS to levels measured in younger mice. In aged mice, LPS induced a progressive loss of DAergic neurons with no recovery for their entire life span, whereas younger mice or aged mice fed with HCT1026 were resistant to systemic LPS-induced DAergic neurodegeneration, underscoring glia as a key pharmacological target for DAergic neuroprotection." @default.
• W1982910460 created "2016-06-24" @default.
• W1982910460 creator A5001302471 @default.
• W1982910460 creator A5013252840 @default.
• W1982910460 creator A5020938978 @default.
• W1982910460 creator A5021181399 @default.
• W1982910460 creator A5031496401 @default.
• W1982910460 creator A5075407827 @default.
• W1982910460 creator A5077892371 @default.
• W1982910460 date "2011-08-01" @default.
• W1982910460 modified "2023-09-23" @default.
• W1982910460 title "Switching the Microglial Harmful Phenotype Promotes Lifelong Restoration of Subtantia Nigra Dopaminergic Neurons from Inflammatory Neurodegeneration in Aged Mice" @default.
• W1982910460 cites W1480874656 @default.
• W1982910460 cites W1530199299 @default.
• W1982910460 cites W1558100964 @default.
• W1982910460 cites W1580441010 @default.
• W1982910460 cites W1587360940 @default.
• W1982910460 cites W1629697287 @default.
• W1982910460 cites W1668344921 @default.
• W1982910460 cites W1771976412 @default.
• W1982910460 cites W1933195856 @default.
• W1982910460 cites W1974924674 @default.
• W1982910460 cites W1975774284 @default.
• W1982910460 cites W1981310043 @default.
• W1982910460 cites W1990000696 @default.
• W1982910460 cites W1990872391 @default.
• W1982910460 cites W1992911806 @default.
• W1982910460 cites W1997962428 @default.
• W1982910460 cites W1999627663 @default.
• W1982910460 cites W1999922500 @default.
• W1982910460 cites W2003321649 @default.
• W1982910460 cites W2003473535 @default.
• W1982910460 cites W2004205580 @default.
• W1982910460 cites W2010414623 @default.
• W1982910460 cites W2011441557 @default.
• W1982910460 cites W2017364016 @default.
• W1982910460 cites W2020656090 @default.
• W1982910460 cites W2021467687 @default.
• W1982910460 cites W2022325044 @default.
• W1982910460 cites W2033558692 @default.
• W1982910460 cites W2039190334 @default.
• W1982910460 cites W2039357975 @default.
• W1982910460 cites W2043122628 @default.
• W1982910460 cites W2043676089 @default.
• W1982910460 cites W2053051103 @default.
• W1982910460 cites W2055750901 @default.
• W1982910460 cites W2056546282 @default.
• W1982910460 cites W2057913943 @default.
• W1982910460 cites W2058594344 @default.
• W1982910460 cites W2064487089 @default.
• W1982910460 cites W2068312274 @default.
• W1982910460 cites W2072210142 @default.
• W1982910460 cites W2079768378 @default.
• W1982910460 cites W2080300101 @default.
• W1982910460 cites W2082510957 @default.
• W1982910460 cites W2084100208 @default.
• W1982910460 cites W2095376584 @default.
• W1982910460 cites W2098097762 @default.
• W1982910460 cites W2098898203 @default.
• W1982910460 cites W2100657323 @default.
• W1982910460 cites W2109759840 @default.
• W1982910460 cites W2111464898 @default.
• W1982910460 cites W2116819366 @default.
• W1982910460 cites W2120331429 @default.
• W1982910460 cites W2120412340 @default.
• W1982910460 cites W2125809720 @default.
• W1982910460 cites W2127563454 @default.
• W1982910460 cites W2131884118 @default.
• W1982910460 cites W2136004258 @default.
• W1982910460 cites W2143500251 @default.
• W1982910460 cites W2145903555 @default.
• W1982910460 cites W2146008698 @default.
• W1982910460 cites W2149298826 @default.
• W1982910460 cites W2151651399 @default.
• W1982910460 cites W2154653323 @default.
• W1982910460 cites W2155790751 @default.
• W1982910460 cites W2158211941 @default.
• W1982910460 cites W2159822434 @default.
• W1982910460 cites W2165738847 @default.
• W1982910460 cites W2168221521 @default.
• W1982910460 cites W2606869650 @default.
• W1982910460 doi "https://doi.org/10.1089/rej.2010.1134" @default.
• W1982910460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21793734" @default.
• W1982910460 hasPublicationYear "2011" @default.
• W1982910460 type Work @default.
• W1982910460 sameAs 1982910460 @default.
• W1982910460 citedByCount "38" @default.
• W1982910460 countsByYear W19829104602012 @default.
• W1982910460 countsByYear W19829104602013 @default.
• W1982910460 countsByYear W19829104602014 @default.
• W1982910460 countsByYear W19829104602016 @default.
• W1982910460 countsByYear W19829104602017 @default.
• W1982910460 countsByYear W19829104602018 @default.
• W1982910460 countsByYear W19829104602019 @default.
• W1982910460 countsByYear W19829104602020 @default.
• W1982910460 countsByYear W19829104602021 @default.
• W1982910460 countsByYear W19829104602022 @default.
• W1982910460 countsByYear W19829104602023 @default.

• next