FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982910588> ?p ?o ?g. }

• W1982910588 endingPage "1083" @default.
• W1982910588 startingPage "1069" @default.
• W1982910588 abstract "Levels of the necessary nutrient vitamin C (ascorbate) are tightly regulated by intestinal absorption, tissue accumulation, and renal reabsorption and excretion. Ascorbate levels are controlled in part by regulation of transport through at least 2 sodium-dependent transporters: Slc23a1 and Slc23a2 (also known as Svct1 and Svct2, respectively). Previous work indicates that Slc23a2 is essential for viability in mice, but the roles of Slc23a1 for viability and in adult physiology have not been determined. To investigate the contributions of Slc23a1 to plasma and tissue ascorbate concentrations in vivo, we generated Slc23a1-/- mice. Compared with wild-type mice, Slc23a1-/- mice increased ascorbate fractional excretion up to 18-fold. Hepatic portal ascorbate accumulation was nearly abolished, whereas intestinal absorption was marginally affected. Both heterozygous and knockout pups born to Slc23a1-/- dams exhibited approximately 45% perinatal mortality, and this was associated with lower plasma ascorbate concentrations in dams and pups. Perinatal mortality of Slc23a1-/- pups born to Slc23a1-/- dams was prevented by ascorbate supplementation during pregnancy. Taken together, these data indicate that ascorbate provided by the dam influenced perinatal survival. Although Slc23a1-/- mice lost as much as 70% of their ascorbate body stores in urine daily, we observed an unanticipated compensatory increase in ascorbate synthesis. These findings indicate a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice." @default.
• W1982910588 created "2016-06-24" @default.
• W1982910588 creator A5014642876 @default.
• W1982910588 creator A5015313694 @default.
• W1982910588 creator A5018244700 @default.
• W1982910588 creator A5024255440 @default.
• W1982910588 creator A5034418946 @default.
• W1982910588 creator A5035480324 @default.
• W1982910588 creator A5039014198 @default.
• W1982910588 creator A5044887457 @default.
• W1982910588 creator A5050388054 @default.
• W1982910588 creator A5067640397 @default.
• W1982910588 creator A5070162484 @default.
• W1982910588 creator A5077568448 @default.
• W1982910588 creator A5077649055 @default.
• W1982910588 date "2010-04-01" @default.
• W1982910588 modified "2023-10-16" @default.
• W1982910588 title "Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice" @default.
• W1982910588 cites W1254410597 @default.
• W1982910588 cites W1489783301 @default.
• W1982910588 cites W1517698775 @default.
• W1982910588 cites W1541013450 @default.
• W1982910588 cites W1835099507 @default.
• W1982910588 cites W1904268912 @default.
• W1982910588 cites W1974744745 @default.
• W1982910588 cites W1977153638 @default.
• W1982910588 cites W1978407431 @default.
• W1982910588 cites W1984661639 @default.
• W1982910588 cites W1986766737 @default.
• W1982910588 cites W1996527523 @default.
• W1982910588 cites W1997409763 @default.
• W1982910588 cites W2002200543 @default.
• W1982910588 cites W2005817335 @default.
• W1982910588 cites W2009293433 @default.
• W1982910588 cites W2016659985 @default.
• W1982910588 cites W2022544791 @default.
• W1982910588 cites W2024365294 @default.
• W1982910588 cites W2029797579 @default.
• W1982910588 cites W2038561595 @default.
• W1982910588 cites W2044597282 @default.
• W1982910588 cites W2052979682 @default.
• W1982910588 cites W2056710889 @default.
• W1982910588 cites W2058618870 @default.
• W1982910588 cites W2062837765 @default.
• W1982910588 cites W2062928336 @default.
• W1982910588 cites W2064526806 @default.
• W1982910588 cites W2064626293 @default.
• W1982910588 cites W2068447726 @default.
• W1982910588 cites W2070532527 @default.
• W1982910588 cites W2084250531 @default.
• W1982910588 cites W2086188302 @default.
• W1982910588 cites W2095081648 @default.
• W1982910588 cites W2096629784 @default.
• W1982910588 cites W2111864962 @default.
• W1982910588 cites W2118094114 @default.
• W1982910588 cites W2125089779 @default.
• W1982910588 cites W2125558666 @default.
• W1982910588 cites W2127672390 @default.
• W1982910588 cites W2127932095 @default.
• W1982910588 cites W2142503533 @default.
• W1982910588 cites W2159099334 @default.
• W1982910588 cites W2159750423 @default.
• W1982910588 cites W2166131221 @default.
• W1982910588 cites W2172069911 @default.
• W1982910588 cites W2320803888 @default.
• W1982910588 cites W2466038009 @default.
• W1982910588 cites W2467577046 @default.
• W1982910588 cites W4248466683 @default.
• W1982910588 cites W4249374289 @default.
• W1982910588 cites W81970610 @default.
• W1982910588 doi "https://doi.org/10.1172/jci39191" @default.
• W1982910588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847422" @default.
• W1982910588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20200446" @default.
• W1982910588 hasPublicationYear "2010" @default.
• W1982910588 type Work @default.
• W1982910588 sameAs 1982910588 @default.
• W1982910588 citedByCount "137" @default.
• W1982910588 countsByYear W19829105882012 @default.
• W1982910588 countsByYear W19829105882013 @default.
• W1982910588 countsByYear W19829105882014 @default.
• W1982910588 countsByYear W19829105882015 @default.
• W1982910588 countsByYear W19829105882016 @default.
• W1982910588 countsByYear W19829105882017 @default.
• W1982910588 countsByYear W19829105882018 @default.
• W1982910588 countsByYear W19829105882019 @default.
• W1982910588 countsByYear W19829105882020 @default.
• W1982910588 countsByYear W19829105882021 @default.
• W1982910588 countsByYear W19829105882022 @default.
• W1982910588 countsByYear W19829105882023 @default.
• W1982910588 crossrefType "journal-article" @default.
• W1982910588 hasAuthorship W1982910588A5014642876 @default.
• W1982910588 hasAuthorship W1982910588A5015313694 @default.
• W1982910588 hasAuthorship W1982910588A5018244700 @default.
• W1982910588 hasAuthorship W1982910588A5024255440 @default.
• W1982910588 hasAuthorship W1982910588A5034418946 @default.
• W1982910588 hasAuthorship W1982910588A5035480324 @default.
• W1982910588 hasAuthorship W1982910588A5039014198 @default.
• W1982910588 hasAuthorship W1982910588A5044887457 @default.

• next