FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982912086> ?p ?o ?g. }

• W1982912086 endingPage "283" @default.
• W1982912086 startingPage "275" @default.
• W1982912086 abstract "Arabidopsisthaliana NADPH:thioredoxin reductase (TR, EC 1.6.4.5) catalyzed redox cycling of aromatic nitrocompounds, including the explosives 2,4,6-trinitrotoluene and tetryl, and the herbicide 3,5-dinitro-o-cresol. The yield of nitro anion radicals was equal to 70–90%. Redox cycling of tetryl was accompanied by formation of N-methylpicramide. Bimolecular rate constants of nitroaromatic reduction (kcat/Km) and reaction catalytic constants (kcat) increased upon an increase in oxidant single-electron reduction potential (E17). Using compounds with an unknown E17 value, the reactivity of TR increased parallelly to the increase in reactivity of ferredoxin:NADP+ reductase of Anabaena PCC 7119 (EC 1.18.1.2). This indicated that the main factor determining reactivity of nitroaromatics towards TR was their energetics of single-electron reduction. Incubation of reduced TR in the presence of tetryl or 2,4-dinitrochlorobenzene resulted in a loss of thioredoxin reductase activity, most probably due to modification of reduced catalytic disulfide, whereas nitroreductase reaction rates were unchanged. This means that on the analogy of quinone reduction by TR (D. Bironait≐, Ž. Anusevičius, J.-P. Jacquot, N. Č≐nas, Biochim. Biophys. Acta 1383 (1998) 82–92), FAD and not catalytic disulfide of TR was responsible for the reduction of nitroaromatics. Tetryl, 2,4,6-trinitrotoluene and thioredoxin increased the FAD fluorescence intensity of TR. This finding suggests that nitroaromatics may bind close to the thioredoxin-binding site at the catalytic disulfide domain of TR, and induce a conformational change of enzymes (S.B. Mulrooney, C.H. Williams Jr., Protein Sci. 6 (1997) 2188–2195). Our data indicate that certain nitroaromatic herbicides, explosives and other classes of xenobiotics may interfere with the reduction of thioredoxin by plant TR, and confer prooxidant properties to this antioxidant enzyme." @default.
• W1982912086 created "2016-06-24" @default.
• W1982912086 creator A5032956026 @default.
• W1982912086 creator A5039684786 @default.
• W1982912086 creator A5076133005 @default.
• W1982912086 creator A5083792979 @default.
• W1982912086 date "1998-09-01" @default.
• W1982912086 modified "2023-10-13" @default.
• W1982912086 title "Nitroreductase reactions of Arabidopsis thaliana thioredoxin reductase" @default.
• W1982912086 cites W1512550098 @default.
• W1982912086 cites W1513390880 @default.
• W1982912086 cites W1517292154 @default.
• W1982912086 cites W1517639918 @default.
• W1982912086 cites W1555938743 @default.
• W1982912086 cites W1605560583 @default.
• W1982912086 cites W1622224404 @default.
• W1982912086 cites W1782885961 @default.
• W1982912086 cites W1881010148 @default.
• W1982912086 cites W1966059212 @default.
• W1982912086 cites W1966263769 @default.
• W1982912086 cites W1967300939 @default.
• W1982912086 cites W1967650766 @default.
• W1982912086 cites W1979424160 @default.
• W1982912086 cites W1982653932 @default.
• W1982912086 cites W2000878126 @default.
• W1982912086 cites W2007317080 @default.
• W1982912086 cites W2010277381 @default.
• W1982912086 cites W2016535624 @default.
• W1982912086 cites W2021451290 @default.
• W1982912086 cites W2024263678 @default.
• W1982912086 cites W2027602317 @default.
• W1982912086 cites W2031653939 @default.
• W1982912086 cites W2031895027 @default.
• W1982912086 cites W2031904472 @default.
• W1982912086 cites W2034877559 @default.
• W1982912086 cites W2039759271 @default.
• W1982912086 cites W2045827825 @default.
• W1982912086 cites W2053472300 @default.
• W1982912086 cites W2058159400 @default.
• W1982912086 cites W2060719551 @default.
• W1982912086 cites W2069254089 @default.
• W1982912086 cites W2072097917 @default.
• W1982912086 cites W2121926391 @default.
• W1982912086 cites W2164150116 @default.
• W1982912086 cites W2797857252 @default.
• W1982912086 doi "https://doi.org/10.1016/s0005-2728(98)00128-5" @default.
• W1982912086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9814841" @default.
• W1982912086 hasPublicationYear "1998" @default.
• W1982912086 type Work @default.
• W1982912086 sameAs 1982912086 @default.
• W1982912086 citedByCount "36" @default.
• W1982912086 countsByYear W19829120862012 @default.
• W1982912086 countsByYear W19829120862014 @default.
• W1982912086 countsByYear W19829120862015 @default.
• W1982912086 countsByYear W19829120862016 @default.
• W1982912086 countsByYear W19829120862018 @default.
• W1982912086 countsByYear W19829120862020 @default.
• W1982912086 countsByYear W19829120862021 @default.
• W1982912086 crossrefType "journal-article" @default.
• W1982912086 hasAuthorship W1982912086A5032956026 @default.
• W1982912086 hasAuthorship W1982912086A5039684786 @default.
• W1982912086 hasAuthorship W1982912086A5076133005 @default.
• W1982912086 hasAuthorship W1982912086A5083792979 @default.
• W1982912086 hasBestOaLocation W19829120861 @default.
• W1982912086 hasConcept C121332964 @default.
• W1982912086 hasConcept C134651460 @default.
• W1982912086 hasConcept C142724271 @default.
• W1982912086 hasConcept C147789679 @default.
• W1982912086 hasConcept C148898269 @default.
• W1982912086 hasConcept C155647269 @default.
• W1982912086 hasConcept C161790260 @default.
• W1982912086 hasConcept C17525397 @default.
• W1982912086 hasConcept C178790620 @default.
• W1982912086 hasConcept C181199279 @default.
• W1982912086 hasConcept C185592680 @default.
• W1982912086 hasConcept C204787440 @default.
• W1982912086 hasConcept C2776910235 @default.
• W1982912086 hasConcept C2777737464 @default.
• W1982912086 hasConcept C2778921574 @default.
• W1982912086 hasConcept C2779268744 @default.
• W1982912086 hasConcept C2781326480 @default.
• W1982912086 hasConcept C3623737 @default.
• W1982912086 hasConcept C41183919 @default.
• W1982912086 hasConcept C52859227 @default.
• W1982912086 hasConcept C55493867 @default.
• W1982912086 hasConcept C55904794 @default.
• W1982912086 hasConcept C56856141 @default.
• W1982912086 hasConcept C62520636 @default.
• W1982912086 hasConcept C70412867 @default.
• W1982912086 hasConcept C71240020 @default.
• W1982912086 hasConcept C71924100 @default.
• W1982912086 hasConcept C75473681 @default.
• W1982912086 hasConcept C93391505 @default.
• W1982912086 hasConceptScore W1982912086C121332964 @default.
• W1982912086 hasConceptScore W1982912086C134651460 @default.
• W1982912086 hasConceptScore W1982912086C142724271 @default.
• W1982912086 hasConceptScore W1982912086C147789679 @default.
• W1982912086 hasConceptScore W1982912086C148898269 @default.

• next