FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982912165> ?p ?o ?g. }

• W1982912165 endingPage "136" @default.
• W1982912165 startingPage "123" @default.
• W1982912165 abstract "Death may be the consequence of natural or unnatural causes, such as accidents, homicide, and suicide, which have no relationship to the disease of epilepsy. Direct causes of death include status epilepticus, and indirect causes may be head trauma or drowning subsequent to a seizure. When death occurs suddenly and without explanation, the term sudden unexpected unexplained death is used. Unexplained is a term that clinicians and research scientists are working to clarify. Numerous preclinical animal studies have been conducted as models for sudden death and have led to clinical studies in persons with epilepsy. These studies show that sympathetic nerve stimulation, ouabain, or coronary occlusion increased temporal dispersion of recovery of ventricular excitability and led to an underlying electrical instability that predisposed the ventricular myocardium to arrhythmia. Cardiac arrhythmias in an animal model for ouabain-induced toxicity were associated with neural autonomic dysfunction. Neural discharges were characterized by increases, decreases, or no change in the discharge of postganglionic cardiac sympathetic nerves monitored simultaneously, predisposingto cardiac arrhythmia. Stimulation of the sympathetic ventrolateral cardiac nerve produced a shift in the origin of the pacemaker and tachyarrhythmias because the nerve is not uniformly distributed to the various regions of the heart but is localized to the atrioventricular junctional and ventricular regions. Such nonuniform distribution of sympathetic nerves would also contribute to initiation of arrhythmia as a nonuniform neural discharge occurred. Studies examining the physiology and pharmacology of this finding in multiple animal models found that subconvulsant, interictal discharge was associated with autonomic cardiac neural nonuniform discharge and cardiac arrhythmias. As a result of further investigations, Lathers and Schraeder edited a book in 1990 that summarized the clinical problem of sudden unexpected death and epilepsy (SUDEP). The contributors concluded that there was a paucity of clinical data addressing the mechanism of death. Regulatory response resulting from the consequent increased awareness of SUDEP occurred in 1993, when the FDA focused attention of practitioners and pharmaceutical manufacturers on the question of whether use of anticonvulsant drugs contributes to or prevents sudden unexpected death in epileptic persons. The FDA-convened panel of scientists considered the prevalence of sudden unexpected death in patients involved in studies associated with developing new anticonvulsant drugs and reviewed data on the risk of sudden unexpected death in patients taking lamotrigine. The risk of SUDEP was no different from that found in the young epilepsy population in general. Estimated SUDEP rates in patients receiving the new anticonvulsant drugs lamotrigine, gabapentin, topiramate, tigabine, and zonisamide were found to be similar to those in patients receiving standard anticonvulsant drugs, suggesting that SUDEP rates reflect population rates and not a specific drug effect. The FDA required warning labels on the risk of SUDEP in association with the use of each of the above-mentioned drugs. Another effect of bringing SUDEP to the attention of epilepsy researchers has been the expansion of basic science and the development of epidemiological and clinical studies directed at this phenomenon. Results from some of these studies are discussed in this article." @default.
• W1982912165 created "2016-06-24" @default.
• W1982912165 creator A5025421407 @default.
• W1982912165 creator A5065437946 @default.
• W1982912165 date "2002-02-01" @default.
• W1982912165 modified "2023-09-27" @default.
• W1982912165 title "Clinical Pharmacology: Drugs as a Benefit and/or Risk in Sudden Unexpected Death in Epilepsy?" @default.
• W1982912165 cites W1764269555 @default.
• W1982912165 cites W1967566702 @default.
• W1982912165 cites W1967990261 @default.
• W1982912165 cites W1969209533 @default.
• W1982912165 cites W1971169836 @default.
• W1982912165 cites W1973650482 @default.
• W1982912165 cites W1975932512 @default.
• W1982912165 cites W1977801258 @default.
• W1982912165 cites W1980849446 @default.
• W1982912165 cites W1992526301 @default.
• W1982912165 cites W1993757735 @default.
• W1982912165 cites W1995337571 @default.
• W1982912165 cites W1996865720 @default.
• W1982912165 cites W2000931063 @default.
• W1982912165 cites W2001461957 @default.
• W1982912165 cites W2002848568 @default.
• W1982912165 cites W2005307278 @default.
• W1982912165 cites W2005544030 @default.
• W1982912165 cites W2005826646 @default.
• W1982912165 cites W2006474040 @default.
• W1982912165 cites W2007591454 @default.
• W1982912165 cites W2008344433 @default.
• W1982912165 cites W2008818621 @default.
• W1982912165 cites W2012061124 @default.
• W1982912165 cites W2012700518 @default.
• W1982912165 cites W2019076658 @default.
• W1982912165 cites W2019098497 @default.
• W1982912165 cites W2023678337 @default.
• W1982912165 cites W2026232526 @default.
• W1982912165 cites W2026851367 @default.
• W1982912165 cites W2031002096 @default.
• W1982912165 cites W2034803449 @default.
• W1982912165 cites W2037924165 @default.
• W1982912165 cites W2038171317 @default.
• W1982912165 cites W2039596041 @default.
• W1982912165 cites W2051677264 @default.
• W1982912165 cites W2052073198 @default.
• W1982912165 cites W2054354352 @default.
• W1982912165 cites W2054674327 @default.
• W1982912165 cites W2056897142 @default.
• W1982912165 cites W2057539773 @default.
• W1982912165 cites W2059032360 @default.
• W1982912165 cites W2060378918 @default.
• W1982912165 cites W2061437743 @default.
• W1982912165 cites W2067463429 @default.
• W1982912165 cites W2068377689 @default.
• W1982912165 cites W2069559288 @default.
• W1982912165 cites W2070020390 @default.
• W1982912165 cites W2074413594 @default.
• W1982912165 cites W2077342620 @default.
• W1982912165 cites W2079405034 @default.
• W1982912165 cites W2081829798 @default.
• W1982912165 cites W2083832411 @default.
• W1982912165 cites W2086259303 @default.
• W1982912165 cites W2087441680 @default.
• W1982912165 cites W2088072875 @default.
• W1982912165 cites W2089050526 @default.
• W1982912165 cites W2090622173 @default.
• W1982912165 cites W2091144818 @default.
• W1982912165 cites W2101288619 @default.
• W1982912165 cites W2108802889 @default.
• W1982912165 cites W2110926310 @default.
• W1982912165 cites W2115797408 @default.
• W1982912165 cites W2115827974 @default.
• W1982912165 cites W2121713305 @default.
• W1982912165 cites W2133916744 @default.
• W1982912165 cites W2134359892 @default.
• W1982912165 cites W2136384491 @default.
• W1982912165 cites W2141454732 @default.
• W1982912165 cites W2143680625 @default.
• W1982912165 cites W2146791878 @default.
• W1982912165 cites W2147494049 @default.
• W1982912165 cites W2151371412 @default.
• W1982912165 cites W2158742835 @default.
• W1982912165 cites W2164373058 @default.
• W1982912165 cites W2165257441 @default.
• W1982912165 cites W2316405728 @default.
• W1982912165 cites W2318531018 @default.
• W1982912165 cites W2427549346 @default.
• W1982912165 cites W4234378314 @default.
• W1982912165 cites W45488840 @default.
• W1982912165 doi "https://doi.org/10.1177/00912700222011157" @default.
• W1982912165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11831534" @default.
• W1982912165 hasPublicationYear "2002" @default.
• W1982912165 type Work @default.
• W1982912165 sameAs 1982912165 @default.
• W1982912165 citedByCount "51" @default.
• W1982912165 countsByYear W19829121652012 @default.
• W1982912165 countsByYear W19829121652013 @default.
• W1982912165 countsByYear W19829121652016 @default.
• W1982912165 countsByYear W19829121652019 @default.

• next