FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982912456> ?p ?o ?g. }

• W1982912456 endingPage "2058" @default.
• W1982912456 startingPage "2047" @default.
• W1982912456 abstract "In living organisms, biological molecules often organize into multicomponent complexes. Such assemblies consist of various proteins and carry out essential functions, ranging from cell division, transport, and energy transduction to catalysis, signaling, and viral infectivity. To understand the biological functions of these assemblies, in both healthy and disease states, researchers need to study their three-dimensional architecture and molecular dynamics. To date, the large size, the lack of inherent long-range order, and insolubility have made atomic resolution studies of many protein assemblies challenging or impractical using traditional structural biology methods such as X-ray diffraction and solution NMR spectroscopy. In the past 10 years, we have focused our work on the development and application of magic angle spinning solid-state NMR (MAS NMR) methods to characterize large protein assemblies at atomic-level resolution. In this Account, we discuss the rapid progress in the field of MAS NMR spectroscopy, citing work from our laboratory and others on methodological developments that have facilitated the in-depth analysis of biologically important protein assemblies. We emphasize techniques that yield enhanced sensitivity and resolution, such as fast MAS (spinning frequencies of 40 kHz and above) and nonuniform sampling protocols for data acquisition and processing. We also discuss the experiments for gaining distance restraints and for recoupling anisotropic tensorial interactions under fast MAS conditions. We give an overview of sample preparation approaches when working with protein assemblies. Following the overview of contemporary MAS NMR methods, we present case studies into the structure and dynamics of two classes of biological systems under investigation in our laboratory. We will first turn our attention to cytoskeletal microtubule motor proteins including mammalian dynactin and dynein light chain 8. We will then discuss protein assemblies from the HIV-1 retrovirus." @default.
• W1982912456 created "2016-06-24" @default.
• W1982912456 creator A5005414489 @default.
• W1982912456 creator A5028040749 @default.
• W1982912456 creator A5044041420 @default.
• W1982912456 creator A5062717638 @default.
• W1982912456 creator A5069645886 @default.
• W1982912456 date "2013-02-13" @default.
• W1982912456 modified "2023-10-12" @default.
• W1982912456 title "Probing Structure and Dynamics of Protein Assemblies by Magic Angle Spinning NMR Spectroscopy" @default.
• W1982912456 cites W1976932660 @default.
• W1982912456 cites W1978941900 @default.
• W1982912456 cites W1984399334 @default.
• W1982912456 cites W1986999419 @default.
• W1982912456 cites W1990204801 @default.
• W1982912456 cites W1998812450 @default.
• W1982912456 cites W2003578495 @default.
• W1982912456 cites W2004154860 @default.
• W1982912456 cites W2009207572 @default.
• W1982912456 cites W2014490126 @default.
• W1982912456 cites W2016476932 @default.
• W1982912456 cites W2018830150 @default.
• W1982912456 cites W2018904815 @default.
• W1982912456 cites W2022644397 @default.
• W1982912456 cites W2025799912 @default.
• W1982912456 cites W2027998345 @default.
• W1982912456 cites W2034791165 @default.
• W1982912456 cites W2035628504 @default.
• W1982912456 cites W2042827782 @default.
• W1982912456 cites W2047255928 @default.
• W1982912456 cites W2047941761 @default.
• W1982912456 cites W2055546280 @default.
• W1982912456 cites W2058581889 @default.
• W1982912456 cites W2060067250 @default.
• W1982912456 cites W2063603085 @default.
• W1982912456 cites W2067836093 @default.
• W1982912456 cites W2072534308 @default.
• W1982912456 cites W2074219349 @default.
• W1982912456 cites W2075501239 @default.
• W1982912456 cites W2079137593 @default.
• W1982912456 cites W2087430045 @default.
• W1982912456 cites W2089464030 @default.
• W1982912456 cites W2089914156 @default.
• W1982912456 cites W2092169379 @default.
• W1982912456 cites W2094692623 @default.
• W1982912456 cites W2096526911 @default.
• W1982912456 cites W2109691238 @default.
• W1982912456 cites W2123083860 @default.
• W1982912456 cites W2134869983 @default.
• W1982912456 cites W2147360655 @default.
• W1982912456 cites W2165938053 @default.
• W1982912456 cites W4229921847 @default.
• W1982912456 cites W613018903 @default.
• W1982912456 doi "https://doi.org/10.1021/ar300309s" @default.
• W1982912456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3748245" @default.
• W1982912456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23402263" @default.
• W1982912456 hasPublicationYear "2013" @default.
• W1982912456 type Work @default.
• W1982912456 sameAs 1982912456 @default.
• W1982912456 citedByCount "73" @default.
• W1982912456 countsByYear W19829124562013 @default.
• W1982912456 countsByYear W19829124562014 @default.
• W1982912456 countsByYear W19829124562015 @default.
• W1982912456 countsByYear W19829124562016 @default.
• W1982912456 countsByYear W19829124562017 @default.
• W1982912456 countsByYear W19829124562018 @default.
• W1982912456 countsByYear W19829124562019 @default.
• W1982912456 countsByYear W19829124562020 @default.
• W1982912456 countsByYear W19829124562021 @default.
• W1982912456 countsByYear W19829124562022 @default.
• W1982912456 countsByYear W19829124562023 @default.
• W1982912456 crossrefType "journal-article" @default.
• W1982912456 hasAuthorship W1982912456A5005414489 @default.
• W1982912456 hasAuthorship W1982912456A5028040749 @default.
• W1982912456 hasAuthorship W1982912456A5044041420 @default.
• W1982912456 hasAuthorship W1982912456A5062717638 @default.
• W1982912456 hasAuthorship W1982912456A5069645886 @default.
• W1982912456 hasBestOaLocation W19829124562 @default.
• W1982912456 hasConcept C121332964 @default.
• W1982912456 hasConcept C147597530 @default.
• W1982912456 hasConcept C153202636 @default.
• W1982912456 hasConcept C154815118 @default.
• W1982912456 hasConcept C159467904 @default.
• W1982912456 hasConcept C171250308 @default.
• W1982912456 hasConcept C178790620 @default.
• W1982912456 hasConcept C185592680 @default.
• W1982912456 hasConcept C186060115 @default.
• W1982912456 hasConcept C188027245 @default.
• W1982912456 hasConcept C192562407 @default.
• W1982912456 hasConcept C2775981520 @default.
• W1982912456 hasConcept C32891209 @default.
• W1982912456 hasConcept C46141821 @default.
• W1982912456 hasConcept C59593255 @default.
• W1982912456 hasConcept C62520636 @default.
• W1982912456 hasConcept C66974803 @default.
• W1982912456 hasConcept C84935128 @default.
• W1982912456 hasConcept C86803240 @default.
• W1982912456 hasConceptScore W1982912456C121332964 @default.

• next