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• W1982912783 abstract "The in-vivo effects of systemic administration of recombinant human interleukin 1β (rIL-1β) were studied in the mouse contact-sensitivity model, rIL-1β in a single dose of 20 μg injected intraperitoneally 72–48 h before or 2–24 h after sensitization suppressed contact sensitivity. Given before challenge rIL-1β modulated the response in a biphasic way with an enhancement at 48 h and a suppression at 2 h before challenge. Only microgram doses of rIL-1β could enhance the contact sensitivity at 48 h, while microgram doses of rIL-1β at 2 h before challenge suppressed and nanogram doses enhanced the response. Treatment with indomethacin could only abrogate the effects of nanogram doses of rIL-1β. Measurements of the thickness of unchallenged control ears revealed that rIL-1β by itself could cause a small but significant increase in thickness depending on the dose and the time of administration." @default.
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• W1982912783 date "1992-02-01" @default.
• W1982912783 modified "2023-09-29" @default.
• W1982912783 title "In-vivo administration of interleukin 1 both enhances and suppresses contact sensitivity in the mouse" @default.
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• W1982912783 doi "https://doi.org/10.1111/j.1365-2133.1992.tb07808.x" @default.
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