Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982912912> ?p ?o ?g. }
- W1982912912 endingPage "128" @default.
- W1982912912 startingPage "119" @default.
- W1982912912 abstract "Colon carcinoma represents a major problem in oncology, since this type of cancer responds poorly to conventional chemotherapy. Many groups are actively involved in the search of new experimental strategies to bypass this problem. We investigated the effects of 2-methoxyestradiol (2-ME), which derives from the NADPH-dependent cytochrome P450 metabolism of 17β-estradiol. This compound has raised much interest in the past few decades for its inhibitory effects on the growth of cancer cells of different origin; however, little is known about its use on colon carcinoma-derived cell lines. In the present study, we investigated the effects of 2-ME on cell proliferation and cell cycle of two human colon carcinoma cell lines, namely HCT116 and SW613-B3. Our results showed a net anti-proliferative effect of 2-ME on both cell lines, which is accompanied by cell cycle arrest; moreover, we demonstrated that 2-ME is able to induce apoptosis as well as autophagy. This body of evidence points out that 2-ME could be considered as a promising tool against colon carcinoma." @default.
- W1982912912 created "2016-06-24" @default.
- W1982912912 creator A5010325060 @default.
- W1982912912 creator A5037226578 @default.
- W1982912912 creator A5061342251 @default.
- W1982912912 creator A5077483997 @default.
- W1982912912 creator A5087215059 @default.
- W1982912912 date "2011-01-01" @default.
- W1982912912 modified "2023-09-23" @default.
- W1982912912 title "2-Methoxyestradiol: New perspectives in colon carcinoma treatment" @default.
- W1982912912 cites W1496861468 @default.
- W1982912912 cites W1607859310 @default.
- W1982912912 cites W1820568833 @default.
- W1982912912 cites W1876742335 @default.
- W1982912912 cites W1963911542 @default.
- W1982912912 cites W1963995164 @default.
- W1982912912 cites W1965987801 @default.
- W1982912912 cites W1966704219 @default.
- W1982912912 cites W1970203467 @default.
- W1982912912 cites W1970708444 @default.
- W1982912912 cites W1974660718 @default.
- W1982912912 cites W1978270862 @default.
- W1982912912 cites W1983964043 @default.
- W1982912912 cites W1989958427 @default.
- W1982912912 cites W1990532502 @default.
- W1982912912 cites W1996809518 @default.
- W1982912912 cites W1997788361 @default.
- W1982912912 cites W1998948981 @default.
- W1982912912 cites W2003292783 @default.
- W1982912912 cites W2007337036 @default.
- W1982912912 cites W2012921202 @default.
- W1982912912 cites W2014007576 @default.
- W1982912912 cites W2019376113 @default.
- W1982912912 cites W2023169350 @default.
- W1982912912 cites W2044442049 @default.
- W1982912912 cites W2045601601 @default.
- W1982912912 cites W2047544660 @default.
- W1982912912 cites W2047817078 @default.
- W1982912912 cites W2048863570 @default.
- W1982912912 cites W2051273138 @default.
- W1982912912 cites W2059583791 @default.
- W1982912912 cites W2063666824 @default.
- W1982912912 cites W2065126270 @default.
- W1982912912 cites W2069247512 @default.
- W1982912912 cites W2069654165 @default.
- W1982912912 cites W2069821688 @default.
- W1982912912 cites W2070182298 @default.
- W1982912912 cites W2071999898 @default.
- W1982912912 cites W2078604774 @default.
- W1982912912 cites W2079605491 @default.
- W1982912912 cites W2085139762 @default.
- W1982912912 cites W2101885479 @default.
- W1982912912 cites W2106345790 @default.
- W1982912912 cites W2107846985 @default.
- W1982912912 cites W2109118524 @default.
- W1982912912 cites W2115726636 @default.
- W1982912912 cites W2119619939 @default.
- W1982912912 cites W2127428044 @default.
- W1982912912 cites W2132006424 @default.
- W1982912912 cites W2134832683 @default.
- W1982912912 cites W2139711019 @default.
- W1982912912 cites W2144009784 @default.
- W1982912912 cites W2144277227 @default.
- W1982912912 cites W2147339968 @default.
- W1982912912 cites W2148526147 @default.
- W1982912912 cites W2159754384 @default.
- W1982912912 cites W2161322323 @default.
- W1982912912 cites W2161714661 @default.
- W1982912912 cites W2163368660 @default.
- W1982912912 cites W2166435019 @default.
- W1982912912 cites W2168229293 @default.
- W1982912912 cites W2187963245 @default.
- W1982912912 cites W2315670997 @default.
- W1982912912 cites W2322083085 @default.
- W1982912912 cites W2325600619 @default.
- W1982912912 cites W2404021914 @default.
- W1982912912 doi "https://doi.org/10.1016/j.mce.2010.08.017" @default.
- W1982912912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20816916" @default.
- W1982912912 hasPublicationYear "2011" @default.
- W1982912912 type Work @default.
- W1982912912 sameAs 1982912912 @default.
- W1982912912 citedByCount "19" @default.
- W1982912912 countsByYear W19829129122012 @default.
- W1982912912 countsByYear W19829129122013 @default.
- W1982912912 countsByYear W19829129122014 @default.
- W1982912912 countsByYear W19829129122015 @default.
- W1982912912 countsByYear W19829129122016 @default.
- W1982912912 countsByYear W19829129122018 @default.
- W1982912912 countsByYear W19829129122019 @default.
- W1982912912 countsByYear W19829129122020 @default.
- W1982912912 countsByYear W19829129122022 @default.
- W1982912912 countsByYear W19829129122023 @default.
- W1982912912 crossrefType "journal-article" @default.
- W1982912912 hasAuthorship W1982912912A5010325060 @default.
- W1982912912 hasAuthorship W1982912912A5037226578 @default.
- W1982912912 hasAuthorship W1982912912A5061342251 @default.
- W1982912912 hasAuthorship W1982912912A5077483997 @default.
- W1982912912 hasAuthorship W1982912912A5087215059 @default.