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- W1982913560 abstract "In Response: Eisenach et al. correctly pointed out the importance of animal neurotoxicity testing before clinical use. In fact, we were reluctant to publish these data because we know that only a few drugs, such as local anesthetics and morphine, are allowed for intraspinal use. We thought that the neurotoxicity is usually related to the presence of preservatives such as benzyl alcohol, and we believed that preservative-free diluted verapamil (5 mg in 10 mL of local anesthetic) would not have any neurotoxic effect. We agree that continued use of verapamil epidurally in a clinical setting should not be performed before preclinical toxicity testing or before permission by drug regulatory agencies. Huhn Choe, MD Department of Anesthesiology; Chonbuk National University; Chonbuk, 561-712 Korea" @default.
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- W1982913560 date "1998-11-01" @default.
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- W1982913560 title "New Epidural Drugs" @default.
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