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- W1982914598 abstract "Translesion DNA synthesis is a mechanism of DNA damage tolerance, and mono-ubiquitination of proliferating cell nuclear antigen (PCNA) is considered to play a key role in regulating the switch from replicative to translesion DNA polymerases (pols). In this study, we analyzed effects of a replicative pol δ on PCNA mono-ubiquitination with the ubiquitin-conjugating enzyme and ligase UBE2A/HHR6A/RAD6A–RAD18. The results revealed that PCNA interacting with pol δ is a better target for ubiquitination, and PCNA mono-ubiquitination could be coupled with DNA replication. Consequently, we could reconstitute replication-coupled switching between pol δ and a translesion pol, pol η, on an ultraviolet-light-irradiated template. With this system, we obtained direct evidence that polymerase switching reactions are stimulated by mono-ubiquitination of PCNA, depending on a function of the ubiquitin binding zinc finger domain of pol η. This study provides a framework for detailed analyses of molecular mechanisms of human pol switching and regulation of translesion DNA synthesis." @default.
- W1982914598 created "2016-06-24" @default.
- W1982914598 creator A5001973313 @default.
- W1982914598 creator A5040871390 @default.
- W1982914598 creator A5051979761 @default.
- W1982914598 date "2010-02-01" @default.
- W1982914598 modified "2023-09-23" @default.
- W1982914598 title "DNA Replication-Coupled PCNA Mono-Ubiquitination and Polymerase Switching in a Human In Vitro System" @default.
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- W1982914598 doi "https://doi.org/10.1016/j.jmb.2010.01.003" @default.
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