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- W1982925920 abstract "The atria have dual physiologic roles, serving both to facilitate ventricular filling and acting as sensors for blood volume, releasing natriuretic peptides that promote renal sodium excretion when filling pressures are elevated. While the atria typically operate with low diastolic pressures, they adapt rapidly to increased pressures with the development of chamber thinning and dilatation. Dilatation is limited by fibroblast proliferation and extracellular matrix accumulation that increases atrial stiffness. Atrial structural remodeling in response to hemodynamic overload is characterized by matrix metalloprotease activation, fibroblast proliferation, and increased abundance of extracellular matrix components. 1 Burstein B. Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol. 2008; 51: 802-809 Abstract Full Text Full Text PDF PubMed Scopus (918) Google Scholar N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atriaHeart RhythmVol. 9Issue 7PreviewProphylactic supplementation with omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The effect of PUFAs given after cardiac injury has occurred is unknown. Full-Text PDF" @default.
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- W1982925920 date "2012-07-01" @default.
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- W1982925920 title "Fish oil for atrial fibrillation prevention: Can we intervene soon enough to make a difference?" @default.
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- W1982925920 doi "https://doi.org/10.1016/j.hrthm.2012.03.005" @default.
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