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• W1982940199 abstract "Abstract TGF‐beta is a potent inhibitor of EGF‐induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five‐fold increase, from 2.8 pM to 14.4 pM, in the ID 50 for TGF beta. The effect was dose‐dependent and was significant at concentrations of 10 −6 M NE and greater. The modulation by NE was mediated by the alpha 1 ‐adrenergic receptor as shown by the ability of the alpha 1 antagonist prazosin to block the activity. This effect might be important during liver regeneration in allowing escape of hepatocytes from negative growth control exerted by TGF‐beta." @default.
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• W1982940199 date "1988-06-01" @default.
• W1982940199 modified "2023-10-15" @default.
• W1982940199 title "Norepinephrine modulates the growth‐inhibitory effect of transforming growth factor‐beta in primary rat hepatocyte cultures" @default.
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• W1982940199 doi "https://doi.org/10.1002/jcp.1041350327" @default.
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