Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982940267> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1982940267 endingPage "10519" @default.
- W1982940267 startingPage "10513" @default.
- W1982940267 abstract "α1-Acid glycoprotein (AGP) consists of 183 amino acid residues and 5 carbohydrate chains and binds to basic and neutral drugs as well as steroid hormones. We investigated the structural properties and ligand-binding capacity of AGP under mild acidic conditions and its interactions with liposomes prepared from neutral or anionic lipids and the neutral drug, progesterone. Interestingly, AGP had a unique structure at pH 4.5, at which the tertiary structure changed, whereas the secondary structure remained intact. Furthermore, the binding capacity of AGP for progesterone did not significantly change under these conditions. It was also observed that AGP was strongly bound to the anionic membrane at pH 4.5, forming an α-helix-rich structure from the original β-sheet-rich structure, which significantly decreased the binding capacity of AGP for progesterone. The structural transitions as well as the membrane binding were suppressed by adding NaCl. These results indicate that AGP has a unique structure on the membrane surface under mild acidic conditions. The conformational change induces binding to the membrane aided by electrostatic interaction, and AGP subsequently takes on a predominantly α-helical conformation." @default.
- W1982940267 created "2016-06-24" @default.
- W1982940267 creator A5002353039 @default.
- W1982940267 creator A5026222199 @default.
- W1982940267 creator A5069115477 @default.
- W1982940267 creator A5085122354 @default.
- W1982940267 creator A5089540655 @default.
- W1982940267 date "2004-07-22" @default.
- W1982940267 modified "2023-10-16" @default.
- W1982940267 title "Binding of α<sub>1</sub>-Acid Glycoprotein to Membrane Results in a Unique Structural Change and Ligand Release" @default.
- W1982940267 cites W1508039024 @default.
- W1982940267 cites W1963773907 @default.
- W1982940267 cites W2010939822 @default.
- W1982940267 cites W2014178729 @default.
- W1982940267 cites W2022467870 @default.
- W1982940267 cites W2030915736 @default.
- W1982940267 cites W2068667361 @default.
- W1982940267 cites W2081205015 @default.
- W1982940267 cites W2095402560 @default.
- W1982940267 cites W2115786883 @default.
- W1982940267 cites W2136702130 @default.
- W1982940267 cites W2147520672 @default.
- W1982940267 cites W4254703869 @default.
- W1982940267 doi "https://doi.org/10.1021/bi0400204" @default.
- W1982940267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15301549" @default.
- W1982940267 hasPublicationYear "2004" @default.
- W1982940267 type Work @default.
- W1982940267 sameAs 1982940267 @default.
- W1982940267 citedByCount "37" @default.
- W1982940267 countsByYear W19829402672012 @default.
- W1982940267 countsByYear W19829402672013 @default.
- W1982940267 countsByYear W19829402672015 @default.
- W1982940267 countsByYear W19829402672016 @default.
- W1982940267 countsByYear W19829402672018 @default.
- W1982940267 countsByYear W19829402672019 @default.
- W1982940267 countsByYear W19829402672020 @default.
- W1982940267 countsByYear W19829402672021 @default.
- W1982940267 countsByYear W19829402672022 @default.
- W1982940267 countsByYear W19829402672023 @default.
- W1982940267 crossrefType "journal-article" @default.
- W1982940267 hasAuthorship W1982940267A5002353039 @default.
- W1982940267 hasAuthorship W1982940267A5026222199 @default.
- W1982940267 hasAuthorship W1982940267A5069115477 @default.
- W1982940267 hasAuthorship W1982940267A5085122354 @default.
- W1982940267 hasAuthorship W1982940267A5089540655 @default.
- W1982940267 hasConcept C107824862 @default.
- W1982940267 hasConcept C108625454 @default.
- W1982940267 hasConcept C116569031 @default.
- W1982940267 hasConcept C12554922 @default.
- W1982940267 hasConcept C170493617 @default.
- W1982940267 hasConcept C185592680 @default.
- W1982940267 hasConcept C2777339483 @default.
- W1982940267 hasConcept C2780902042 @default.
- W1982940267 hasConcept C41625074 @default.
- W1982940267 hasConcept C51639874 @default.
- W1982940267 hasConcept C55493867 @default.
- W1982940267 hasConcept C71240020 @default.
- W1982940267 hasConcept C71315377 @default.
- W1982940267 hasConcept C86803240 @default.
- W1982940267 hasConceptScore W1982940267C107824862 @default.
- W1982940267 hasConceptScore W1982940267C108625454 @default.
- W1982940267 hasConceptScore W1982940267C116569031 @default.
- W1982940267 hasConceptScore W1982940267C12554922 @default.
- W1982940267 hasConceptScore W1982940267C170493617 @default.
- W1982940267 hasConceptScore W1982940267C185592680 @default.
- W1982940267 hasConceptScore W1982940267C2777339483 @default.
- W1982940267 hasConceptScore W1982940267C2780902042 @default.
- W1982940267 hasConceptScore W1982940267C41625074 @default.
- W1982940267 hasConceptScore W1982940267C51639874 @default.
- W1982940267 hasConceptScore W1982940267C55493867 @default.
- W1982940267 hasConceptScore W1982940267C71240020 @default.
- W1982940267 hasConceptScore W1982940267C71315377 @default.
- W1982940267 hasConceptScore W1982940267C86803240 @default.
- W1982940267 hasIssue "32" @default.
- W1982940267 hasLocation W19829402671 @default.
- W1982940267 hasLocation W19829402672 @default.
- W1982940267 hasOpenAccess W1982940267 @default.
- W1982940267 hasPrimaryLocation W19829402671 @default.
- W1982940267 hasRelatedWork W1570348606 @default.
- W1982940267 hasRelatedWork W1973479917 @default.
- W1982940267 hasRelatedWork W2056524723 @default.
- W1982940267 hasRelatedWork W2073626691 @default.
- W1982940267 hasRelatedWork W2077448011 @default.
- W1982940267 hasRelatedWork W2097544532 @default.
- W1982940267 hasRelatedWork W2436327472 @default.
- W1982940267 hasRelatedWork W3101357344 @default.
- W1982940267 hasRelatedWork W331080263 @default.
- W1982940267 hasRelatedWork W3140740151 @default.
- W1982940267 hasVolume "43" @default.
- W1982940267 isParatext "false" @default.
- W1982940267 isRetracted "false" @default.
- W1982940267 magId "1982940267" @default.
- W1982940267 workType "article" @default.