FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982940569> ?p ?o ?g. }

• W1982940569 endingPage "1619" @default.
• W1982940569 startingPage "1613" @default.
• W1982940569 abstract "Fentanyl, sufentanil, and alfentanil are commonly used as opioid analgesics. Alfentanil clearance has previously been shown to exhibit an important interindividual variability, which was not observed for fentanyl or sufentanil. Differences in pharmacokinetic parameters of alfentanil have previously been associated with the wide distribution of CYP3A4, the only known hepatic cytochrome P450 monooxygenase (CYP) involved in the conversion of alfentanil to noralfentanil. Little is known about the involvement of CYP enzymes in the oxidative metabolism of fentanyl and sufentanil. Microsomes prepared from different human liver samples were compared for their abilities to metabolize fentanyl, sufentanil and alfentanil, and it was found that disappearance of the three substrates was well correlated with immunoreactive CYP3A4 contents but not with other CYPs, including CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6 and CYP2E1. Specific known inhibitors of CYP enzymes gave similar results, whereas the use of recombinant human CYP enzymes expressed in yeast provided information about the possible involvement of other CYPs than CYP3A4 in the biotransformation of fentanyl and sufentanil. The possible in vivo interaction of fentanyl and sufentanil with other drugs catalyzed by CYP3A4 is also discussed." @default.
• W1982940569 created "2016-06-24" @default.
• W1982940569 creator A5014474356 @default.
• W1982940569 creator A5028433076 @default.
• W1982940569 creator A5047139655 @default.
• W1982940569 creator A5058688162 @default.
• W1982940569 creator A5078897637 @default.
• W1982940569 creator A5090193749 @default.
• W1982940569 date "1997-06-01" @default.
• W1982940569 modified "2023-10-10" @default.
• W1982940569 title "Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil" @default.
• W1982940569 cites W1900675426 @default.
• W1982940569 cites W1951469402 @default.
• W1982940569 cites W1964609099 @default.
• W1982940569 cites W1970648957 @default.
• W1982940569 cites W1979359878 @default.
• W1982940569 cites W1987624495 @default.
• W1982940569 cites W1993263798 @default.
• W1982940569 cites W1995928438 @default.
• W1982940569 cites W1997016310 @default.
• W1982940569 cites W2003524122 @default.
• W1982940569 cites W2008738913 @default.
• W1982940569 cites W2008984280 @default.
• W1982940569 cites W2014281089 @default.
• W1982940569 cites W2015569636 @default.
• W1982940569 cites W2021022758 @default.
• W1982940569 cites W2024008052 @default.
• W1982940569 cites W2026962999 @default.
• W1982940569 cites W2035090151 @default.
• W1982940569 cites W2035987816 @default.
• W1982940569 cites W2038188157 @default.
• W1982940569 cites W2049915814 @default.
• W1982940569 cites W2053243895 @default.
• W1982940569 cites W2054885340 @default.
• W1982940569 cites W2057394991 @default.
• W1982940569 cites W2061539226 @default.
• W1982940569 cites W2061782067 @default.
• W1982940569 cites W2082076628 @default.
• W1982940569 cites W2087556292 @default.
• W1982940569 cites W2090149382 @default.
• W1982940569 cites W2124802093 @default.
• W1982940569 cites W2128226073 @default.
• W1982940569 cites W2151118622 @default.
• W1982940569 cites W2151582572 @default.
• W1982940569 cites W2151988057 @default.
• W1982940569 cites W2160680822 @default.
• W1982940569 cites W2330068990 @default.
• W1982940569 cites W2330885776 @default.
• W1982940569 doi "https://doi.org/10.1016/s0006-2952(96)00893-3" @default.
• W1982940569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9264313" @default.
• W1982940569 hasPublicationYear "1997" @default.
• W1982940569 type Work @default.
• W1982940569 sameAs 1982940569 @default.
• W1982940569 citedByCount "83" @default.
• W1982940569 countsByYear W19829405692012 @default.
• W1982940569 countsByYear W19829405692013 @default.
• W1982940569 countsByYear W19829405692015 @default.
• W1982940569 countsByYear W19829405692016 @default.
• W1982940569 countsByYear W19829405692017 @default.
• W1982940569 countsByYear W19829405692018 @default.
• W1982940569 countsByYear W19829405692019 @default.
• W1982940569 countsByYear W19829405692020 @default.
• W1982940569 countsByYear W19829405692021 @default.
• W1982940569 countsByYear W19829405692022 @default.
• W1982940569 countsByYear W19829405692023 @default.
• W1982940569 crossrefType "journal-article" @default.
• W1982940569 hasAuthorship W1982940569A5014474356 @default.
• W1982940569 hasAuthorship W1982940569A5028433076 @default.
• W1982940569 hasAuthorship W1982940569A5047139655 @default.
• W1982940569 hasAuthorship W1982940569A5058688162 @default.
• W1982940569 hasAuthorship W1982940569A5078897637 @default.
• W1982940569 hasAuthorship W1982940569A5090193749 @default.
• W1982940569 hasConcept C109650736 @default.
• W1982940569 hasConcept C185592680 @default.
• W1982940569 hasConcept C196013638 @default.
• W1982940569 hasConcept C2777019824 @default.
• W1982940569 hasConcept C2781072394 @default.
• W1982940569 hasConcept C2781091344 @default.
• W1982940569 hasConcept C33664856 @default.
• W1982940569 hasConcept C50605568 @default.
• W1982940569 hasConcept C526171541 @default.
• W1982940569 hasConcept C55493867 @default.
• W1982940569 hasConcept C62231903 @default.
• W1982940569 hasConcept C71924100 @default.
• W1982940569 hasConcept C86745063 @default.
• W1982940569 hasConcept C98274493 @default.
• W1982940569 hasConceptScore W1982940569C109650736 @default.
• W1982940569 hasConceptScore W1982940569C185592680 @default.
• W1982940569 hasConceptScore W1982940569C196013638 @default.
• W1982940569 hasConceptScore W1982940569C2777019824 @default.
• W1982940569 hasConceptScore W1982940569C2781072394 @default.
• W1982940569 hasConceptScore W1982940569C2781091344 @default.
• W1982940569 hasConceptScore W1982940569C33664856 @default.
• W1982940569 hasConceptScore W1982940569C50605568 @default.
• W1982940569 hasConceptScore W1982940569C526171541 @default.
• W1982940569 hasConceptScore W1982940569C55493867 @default.
• W1982940569 hasConceptScore W1982940569C62231903 @default.
• W1982940569 hasConceptScore W1982940569C71924100 @default.

• next