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• W1982959314 abstract "The study was conducted to examine the biochemical and biophysical basis for the clinical finding that abstinence reverses the effects of prolonged ethanol consumption. Mitochondrial respiration and contractility of glycerinated heart muscle fibers were chosen as indexes to determine (1) the relative length of time after chronic ethanol consumption required to initiate changes in the myocardium, and (2) the degree of recovery in the study animals after removal of ethanol from their diet. Measurements were made in rats consuming 25 percent ethanol daily for 4,6, or 8 weeks. Analysis revealed a gradual reduction in the maximal rate of isometric tension development, the maximal developed tension and the velocity of shortening at zero load. The time to peak tension gradually increased and mitochondrial respiration steadily decreased with longer periods of ethanol ingestion. The effects occurred earlier and to a greater degree with glutamate, a nicotinamide-adenine dinucleotide-linked substrate, than with succinate, which is flavoprotein-linked. Respiration with glutamate was diminished after 4 weeks of ethanol consumption by 8 percent, after 6 weeks by 19 percent and after 8 weeks by 20 percent. After 8 weeks of ethanol consumption, some rats were given a nonalcoholic diet to assess the effects of abstinence on these two variables. Four weeks after removal of ethanol from the diet, the contractility of glycerinated heart muscle fibers was still significantly diminished. After 8 weeks, and had essentially returned to precontrol levels, but was still reduced by 15 percent. Likewise, mitochondrial respiration had nearly returned to control values after 8 weeks of abstinence. These observations demonstrate that certain biochemical changes in heart muscle produced by ethanol are reversible after cessation of ethanol administration." @default.
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• W1982959314 date "1977-10-01" @default.
• W1982959314 modified "2023-10-17" @default.
• W1982959314 title "Reversibility of mitochondrial and contractile changes in the myocardium after cessation of prolonged ethanol intake" @default.
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• W1982959314 doi "https://doi.org/10.1016/0002-9149(77)90071-6" @default.
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