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- W1982971105 abstract "SUMMARY: To evaluate the possible contribution of atrial natriuretic peptide (ANP) to the development of glomerular hyperfiltration, we examined the effect of nonpeptide competitive antagonist for biological receptors of ANP, HS-142-1, on glomerular filtration rate (GFR) and renal plasma flow (RPF) in diabetic rats. Increased GFR and RPF in diabetic rats were significantly ameliorated by the injection of HS-142-1, while blood pressure remained unchanged. Urinary cyclic GMP excretion was significantly higher in diabetic rats than in control rats and HS-142-1 decreased urinary cGMP excretion significantly. These results indicate that atrial natriuretic peptide contributes to the development of glomerular hyperfiltration and hyperperfusion in diabetes and HS-142-1 might be useful in the treatment of them." @default.
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- W1982971105 date "1994-11-01" @default.
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- W1982971105 title "An antagonist for atrial natriuretic peptide receptors ameliorates glomerular hyperfiltration in diabetic rats" @default.
- W1982971105 doi "https://doi.org/10.1016/0928-4680(94)90568-1" @default.
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