Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982992775> ?p ?o ?g. }
- W1982992775 endingPage "471" @default.
- W1982992775 startingPage "455" @default.
- W1982992775 abstract "Cortical malformations are commonly associated with intractable epilepsy and other developmental disorders. Our studies utilize the tish rat, a spontaneously occurring genetic model of subcortical band heterotopia (SBH) associated with epilepsy, to evaluate the developmental events underlying SBH formation in the neocortex. Our results demonstrate that Pax6+ and Tbr2+ progenitors are mislocalized in tish+/− and tish−/−- neocortex throughout neurogenesis. In addition, mislocalized tish−/− progenitors possess a longer cell cycle than wild type or normally-positioned tish−/− progenitors, owing to a lengthened G2+M+G1 time. This mislocalization is not associated with adherens junction breakdown or loss of radial glial polarity in the ventricular zone (VZ), as assessed by immunohistochemistry against phalloidin (to identify F-actin), aPKC-λ and Par3. However, vimentin immunohistochemistry indicates that the radial glial scaffold is disrupted in the region of the tish−/− heterotopia. Moreover, lineage tracing experiments using in utero electroporation in tish−/− neocortex demonstrate that mislocalized progenitors do not retain contact with the ventricular surface and that ventricular/subventricular zone (SVZ) progenitors produce neurons that migrate into both the heterotopia and cortical plate (CP). Taken together, these findings define a series of developmental errors contributing to SBH formation that differs fundamentally from a primary error in neuronal migration." @default.
- W1982992775 created "2016-06-24" @default.
- W1982992775 creator A5004733051 @default.
- W1982992775 creator A5045913917 @default.
- W1982992775 creator A5077405917 @default.
- W1982992775 date "2011-03-01" @default.
- W1982992775 modified "2023-10-16" @default.
- W1982992775 title "Disturbances in the positioning, proliferation and apoptosis of neural progenitors contribute to subcortical band heterotopia formation" @default.
- W1982992775 cites W1503727145 @default.
- W1982992775 cites W1506357334 @default.
- W1982992775 cites W1562967551 @default.
- W1982992775 cites W1582081614 @default.
- W1982992775 cites W1770734980 @default.
- W1982992775 cites W1865113829 @default.
- W1982992775 cites W1882754681 @default.
- W1982992775 cites W1976626765 @default.
- W1982992775 cites W1981443246 @default.
- W1982992775 cites W1988544711 @default.
- W1982992775 cites W1990935914 @default.
- W1982992775 cites W1992502425 @default.
- W1982992775 cites W1997073575 @default.
- W1982992775 cites W1998569689 @default.
- W1982992775 cites W1999879310 @default.
- W1982992775 cites W1999970417 @default.
- W1982992775 cites W2009495925 @default.
- W1982992775 cites W2022888964 @default.
- W1982992775 cites W2031928696 @default.
- W1982992775 cites W2033349885 @default.
- W1982992775 cites W2037141536 @default.
- W1982992775 cites W2038973062 @default.
- W1982992775 cites W2047452007 @default.
- W1982992775 cites W2055421069 @default.
- W1982992775 cites W2056362247 @default.
- W1982992775 cites W2073500884 @default.
- W1982992775 cites W2079396188 @default.
- W1982992775 cites W2088814620 @default.
- W1982992775 cites W2090143287 @default.
- W1982992775 cites W2110209356 @default.
- W1982992775 cites W2115279938 @default.
- W1982992775 cites W2117556987 @default.
- W1982992775 cites W2119624274 @default.
- W1982992775 cites W2125842400 @default.
- W1982992775 cites W2127220436 @default.
- W1982992775 cites W2131306660 @default.
- W1982992775 cites W2143943557 @default.
- W1982992775 cites W2146044256 @default.
- W1982992775 cites W2147369750 @default.
- W1982992775 cites W2147471332 @default.
- W1982992775 cites W2149695265 @default.
- W1982992775 cites W2154665940 @default.
- W1982992775 cites W2164591386 @default.
- W1982992775 cites W2165376655 @default.
- W1982992775 cites W2165981171 @default.
- W1982992775 cites W2171445737 @default.
- W1982992775 cites W2333640979 @default.
- W1982992775 cites W4229924429 @default.
- W1982992775 doi "https://doi.org/10.1016/j.neuroscience.2010.12.003" @default.
- W1982992775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3058943" @default.
- W1982992775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21145942" @default.
- W1982992775 hasPublicationYear "2011" @default.
- W1982992775 type Work @default.
- W1982992775 sameAs 1982992775 @default.
- W1982992775 citedByCount "16" @default.
- W1982992775 countsByYear W19829927752012 @default.
- W1982992775 countsByYear W19829927752013 @default.
- W1982992775 countsByYear W19829927752014 @default.
- W1982992775 countsByYear W19829927752015 @default.
- W1982992775 countsByYear W19829927752016 @default.
- W1982992775 countsByYear W19829927752017 @default.
- W1982992775 countsByYear W19829927752019 @default.
- W1982992775 countsByYear W19829927752020 @default.
- W1982992775 countsByYear W19829927752021 @default.
- W1982992775 countsByYear W19829927752023 @default.
- W1982992775 crossrefType "journal-article" @default.
- W1982992775 hasAuthorship W1982992775A5004733051 @default.
- W1982992775 hasAuthorship W1982992775A5045913917 @default.
- W1982992775 hasAuthorship W1982992775A5077405917 @default.
- W1982992775 hasBestOaLocation W19829927752 @default.
- W1982992775 hasConcept C105702510 @default.
- W1982992775 hasConcept C136834591 @default.
- W1982992775 hasConcept C1491633281 @default.
- W1982992775 hasConcept C149402561 @default.
- W1982992775 hasConcept C15729860 @default.
- W1982992775 hasConcept C169760540 @default.
- W1982992775 hasConcept C201508349 @default.
- W1982992775 hasConcept C201750760 @default.
- W1982992775 hasConcept C2777222312 @default.
- W1982992775 hasConcept C2777542384 @default.
- W1982992775 hasConcept C2781444307 @default.
- W1982992775 hasConcept C28328180 @default.
- W1982992775 hasConcept C4746552 @default.
- W1982992775 hasConcept C54355233 @default.
- W1982992775 hasConcept C86803240 @default.
- W1982992775 hasConcept C95444343 @default.
- W1982992775 hasConceptScore W1982992775C105702510 @default.
- W1982992775 hasConceptScore W1982992775C136834591 @default.
- W1982992775 hasConceptScore W1982992775C1491633281 @default.
- W1982992775 hasConceptScore W1982992775C149402561 @default.