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- W1983004736 abstract "Abstract Background The plant Pentapetes phoenicea has not been explored scientifically till now. The study was undertaken to establish the in-vitro antiradical property and α-amylase inhibitory activity to establish in-vitro hypoglycemic potential of various fractions of P. phoenicea leaves. Methods The 2,2-diphenyl-1-picrylhydrazyl (DPPH) test widely used to evaluate the antiradical activity of pure compounds or extracts was adopted to ascertain the antiradical property. The in-vitro α-amylase inhibitory assay using starch as a substrate and pancreatic amylase as the enzyme was used to ascertain the in-vitro hypoglycemic activity. Statistical and linear regression analysis was done using GraphPad prism 4.1 software. Results and discussion The results for antiradical property showed promising IC50 22.93 & 36.30 μg/ml for aqueous and ethyl acetate fractions respectively in comparison with standard quercetin 6.089 μg/ml. The in-vitro-hypoglycemic activity of P. phoenicea at graded concentrations on α-amylase activity was observed with IC50 of 60.51, 74.01 μg/ml for ethyl acetate and aqueous fractions respectively as compared to standard drug acarbose with IC50 80.80 μg/ml. Conclusion From the results it was concluded that aqueous & ethyl acetate fractions showed promising IC50 values for in-vitro hypoglycemic activity. The preliminary investigation results confirmed the presence of flavonoids in ethyl acetate fraction, saponin, reducing sugar and tannin in aqueous fraction. Accordingly the antiradical activity and α-amylase activity may be regarded to the flavonoids, tannins and saponins present in the fractions." @default.
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- W1983004736 date "2013-05-01" @default.
- W1983004736 modified "2023-09-26" @default.
- W1983004736 title "In-vitro antiradical and inhibitory potential of Pentapetes phoenicea Linn. leaves against digestive enzymes related to diabetes" @default.
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- W1983004736 doi "https://doi.org/10.1016/j.jopr.2013.04.034" @default.
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