FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983006346> ?p ?o ?g. }

• W1983006346 endingPage "1326" @default.
• W1983006346 startingPage "1315" @default.
• W1983006346 abstract "Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated viral (AAV) vectors has recently been documented in animal models of Parkinson's disease (PD). So far, all studies have utilized a mix of two monocistronic vectors expressing either of the two genes, tyrosine hydroxylase (TH) and GTP cyclohydrolase-1 (GCH1), needed for DOPA production. Here, we present a novel vector design that enables efficient DOPA production from a single AAV vector in rats with complete unilateral dopamine (DA) lesions. Functional efficacy was assessed with drug-induced and spontaneous motor behavioral tests where vector-treated animals showed near complete and stable recovery within 1 month. Recovery of motor function was associated with restoration of extracellular DA levels as assessed by online microdialysis. Histological analysis showed robust transgene expression not only in the striatum but also in overlying cortical areas. In globus pallidus, we noted loss of NeuN staining, which might be due to different sensitivity in neuronal populations to transgene expression. Taken together, we present a single AAV vector design that result in efficient DOPA production and wide-spread transduction. This is a favorable starting point for continued translation toward a therapeutic application, although future studies need to carefully review target region, vector spread and dilution with this approach." @default.
• W1983006346 created "2016-06-24" @default.
• W1983006346 creator A5016980846 @default.
• W1983006346 creator A5021719376 @default.
• W1983006346 creator A5031631254 @default.
• W1983006346 creator A5083016310 @default.
• W1983006346 date "2012-07-01" @default.
• W1983006346 modified "2023-10-06" @default.
• W1983006346 title "Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease" @default.
• W1983006346 cites W1587727277 @default.
• W1983006346 cites W1769569140 @default.
• W1983006346 cites W1874219366 @default.
• W1983006346 cites W1934735114 @default.
• W1983006346 cites W1964549963 @default.
• W1983006346 cites W1965887745 @default.
• W1983006346 cites W1977307368 @default.
• W1983006346 cites W1977376243 @default.
• W1983006346 cites W1983678138 @default.
• W1983006346 cites W2006345152 @default.
• W1983006346 cites W2007904275 @default.
• W1983006346 cites W2008119031 @default.
• W1983006346 cites W2010206955 @default.
• W1983006346 cites W2011873055 @default.
• W1983006346 cites W2012111175 @default.
• W1983006346 cites W2012770364 @default.
• W1983006346 cites W2017990041 @default.
• W1983006346 cites W2023486707 @default.
• W1983006346 cites W2024869784 @default.
• W1983006346 cites W2045736514 @default.
• W1983006346 cites W2048008983 @default.
• W1983006346 cites W2051159468 @default.
• W1983006346 cites W2062206617 @default.
• W1983006346 cites W2062901734 @default.
• W1983006346 cites W2064848179 @default.
• W1983006346 cites W2065723600 @default.
• W1983006346 cites W2066113689 @default.
• W1983006346 cites W2067920593 @default.
• W1983006346 cites W2068231672 @default.
• W1983006346 cites W2071898004 @default.
• W1983006346 cites W2085518524 @default.
• W1983006346 cites W2094832399 @default.
• W1983006346 cites W2097863680 @default.
• W1983006346 cites W2111837903 @default.
• W1983006346 cites W2128033750 @default.
• W1983006346 cites W2130275119 @default.
• W1983006346 cites W2135907949 @default.
• W1983006346 cites W2138709009 @default.
• W1983006346 cites W2141311399 @default.
• W1983006346 cites W2151349288 @default.
• W1983006346 cites W2151497983 @default.
• W1983006346 cites W2154452702 @default.
• W1983006346 cites W2166496419 @default.
• W1983006346 cites W2177094286 @default.
• W1983006346 cites W2337142316 @default.
• W1983006346 cites W4328001158 @default.
• W1983006346 doi "https://doi.org/10.1038/mt.2012.1" @default.
• W1983006346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3392974" @default.
• W1983006346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22294150" @default.
• W1983006346 hasPublicationYear "2012" @default.
• W1983006346 type Work @default.
• W1983006346 sameAs 1983006346 @default.
• W1983006346 citedByCount "27" @default.
• W1983006346 countsByYear W19830063462012 @default.
• W1983006346 countsByYear W19830063462013 @default.
• W1983006346 countsByYear W19830063462014 @default.
• W1983006346 countsByYear W19830063462015 @default.
• W1983006346 countsByYear W19830063462016 @default.
• W1983006346 countsByYear W19830063462017 @default.
• W1983006346 countsByYear W19830063462018 @default.
• W1983006346 countsByYear W19830063462019 @default.
• W1983006346 countsByYear W19830063462020 @default.
• W1983006346 countsByYear W19830063462021 @default.
• W1983006346 countsByYear W19830063462022 @default.
• W1983006346 crossrefType "journal-article" @default.
• W1983006346 hasAuthorship W1983006346A5016980846 @default.
• W1983006346 hasAuthorship W1983006346A5021719376 @default.
• W1983006346 hasAuthorship W1983006346A5031631254 @default.
• W1983006346 hasAuthorship W1983006346A5083016310 @default.
• W1983006346 hasBestOaLocation W19830063461 @default.
• W1983006346 hasConcept C102230213 @default.
• W1983006346 hasConcept C104317684 @default.
• W1983006346 hasConcept C142724271 @default.
• W1983006346 hasConcept C159167319 @default.
• W1983006346 hasConcept C169760540 @default.
• W1983006346 hasConcept C203014093 @default.
• W1983006346 hasConcept C204232928 @default.
• W1983006346 hasConcept C2779134260 @default.
• W1983006346 hasConcept C2779734285 @default.
• W1983006346 hasConcept C2780062018 @default.
• W1983006346 hasConcept C2781100881 @default.
• W1983006346 hasConcept C40767141 @default.
• W1983006346 hasConcept C513476851 @default.
• W1983006346 hasConcept C54355233 @default.
• W1983006346 hasConcept C71924100 @default.
• W1983006346 hasConcept C86803240 @default.
• W1983006346 hasConcept C92087593 @default.
• W1983006346 hasConceptScore W1983006346C102230213 @default.
• W1983006346 hasConceptScore W1983006346C104317684 @default.

• next