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• W1983009247 endingPage "451" @default.
• W1983009247 startingPage "446" @default.
• W1983009247 abstract "<b><i>Background:</i></b> Intercellular adhesion molecule (ICAM)-5 (telencephalin) is an adhesion molecule in telencephalic neurons of the mammalian brain that binds to the leukocyte integrin CD11a/CD18. The authors observed that human cerebral neurons also expressed ICAM-5 and that ICAM-5–mediated neuron–leukocyte binding in cultured hippocampal neurons. This led the authors to examine ICAM-5 expression during clinical CNS inflammation. <b><i>Methods:</i></b> The authors found, by immunoblotting, a 115-kDa soluble form of ICAM-5 (sICAM-5) cleaved from the membrane-bound (130 kDa) ICAM-5, and established an ELISA assay to measure it. CSF samples of patients with acute encephalitis and MS were studied. <b><i>Results:</i></b> sICAM-5 was increased in encephalitis (320 ± 107 ng/mL; n = 25), as compared with patients with MS (128 ± 10 ng/mL; n = 16) and control subjects without CNS disease (137 ± 6 ng/mL; n = 42) (<i>p</i> < 0.001). The concentration of sICAM-5 correlated with the performance in the immediate recall task (<i>p</i> = 0.013) and with the leukocyte count in the CSF (<i>p</i> = 0.02), especially in cases caused by herpes simplex virus (HSV) (<i>r</i> = 0.94; <i>p</i> = 0.002). <b><i>Conclusions:</i></b> sICAM-5 is cleaved from CNS into CSF during acute encephalitis, and it may mediate leukocyte–neuron interactions. sICAM-5 release from cerebral neurons may actively regulate immune responses and leukocyte adhesion during microbial neuroinvasion in humans during encephalitis." @default.
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• W1983009247 date "2002-02-12" @default.
• W1983009247 modified "2023-10-05" @default.
• W1983009247 title "Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis" @default.
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• W1983009247 doi "https://doi.org/10.1212/wnl.58.3.446" @default.
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