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• W1983010242 abstract "Recent studies have reported the detection of rabies viral antigens and virions in astrocytes and microglia of rabies-infected animals. As a first step toward understanding whether these glial cells may be involved in rabies virus replication, persistence, and/or pathogenesis, we explored their potential to be infected in vitro. Primary cultures of murine, feline, and human microglia and astrocytes were infected with several different rabies viruses: two unpassaged street virus isolates, a cell culture-adapted strain, and a mouse brain-passaged strain. Infection, as determined by immunofluorescence, was detected in 15 of the 16 (94%) virus-glial cell combinations. Replication of infectious virus, determined by infectivity assay, was detected in 7 of the 8 (88%) virus-cell combinations. These results show that astrocytes and microglia can be infected by rabies viruses, suggesting that they may have a potential role in disease, perhaps contributing to viral spread, persistence and/or neuronal dysfunction." @default.
• W1983010242 created "2016-06-24" @default.
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• W1983010242 date "1997-05-01" @default.
• W1983010242 modified "2023-09-25" @default.
• W1983010242 title "Rabies viruses infect primary cultures of murine, feline, and human microglia and astrocytes" @default.
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• W1983010242 doi "https://doi.org/10.1007/s007050050136" @default.
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