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• W1983013313 abstract "BACKGROUND The crucial role of CD4 T-cells in anti-tumor immune response is widely recognized, yet the identification of HLA class II-restricted epitopes derived from tumor antigens has lagged behind compared to class I epitopes. This is particularly true for prostate cancer. Based on the hypothesis that successful cancer immunotherapy will likely resemble autoimmunity, we searched for the CD4 T-cell epitopes derived from prostatic proteins that are restricted by human leukocyte antigen (HLA)-DRB1*1501, an allele associated with granulomatous prostatitis (GP), a disease that may have an autoimmune etiology. One of the antigens implicated in the development of autoimmunity in the prostate is prostatic acid phosphatase (PAP), which is also considered a promising target for prostate cancer immunotherapy. METHODS We immunized transgenic (tg) mice engineered to express HLA-DRB1*1501 with human PAP. A library of overlapping 20-mer peptides spanning the entire human PAP sequence was screened in vitro for T-cell recognition by proliferative and interferon (IFN)-γ enzyme-linked immunosorbent spot (ELISPOT) assays. RESULTS We identified two 20-mer peptides, PAP (133–152), and PAP (173–192), that were immunogenic and naturally processed from whole PAP in HLA-DRB1*1501 tg mice. These peptides were also capable of stimulating CD4 T lymphocytes from HLA-DRB1*1501-positive patients with GP and normal donors. CONCLUSIONS These peptides can be used for the design of a new generation of peptide-based vaccines against prostate cancer. The study can also be helpful in understanding the role of autoimmunity in the development of some forms of chronic prostatitis. Prostate 67: 1019–1028, 2007. © 2007 Wiley-Liss, Inc." @default.
• W1983013313 created "2016-06-24" @default.
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• W1983013313 date "2007-01-01" @default.
• W1983013313 modified "2023-10-14" @default.
• W1983013313 title "Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase" @default.
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• W1983013313 doi "https://doi.org/10.1002/pros.20575" @default.
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